左卡尼汀配合甲钴胺治疗血透致尿毒症性周围神经病变的临床疗效观察

Observation on the Clinical Efficacy of Levocarnitine Combined with Mecobalamine in the Treatment of Hemodialysis-Induced Uremic Peripheral Neuropathy

目的观察左卡尼汀配合甲钴胺治疗血透致尿毒症性周围神经病变患者的临床疗效。方法将2013年3月至2018年3月我院收治的146例血透致尿毒症性周围神经病变患者随机分为两组,每组73例。对照组采用左卡尼汀治疗,观察组采用左卡尼汀配合甲钴胺治疗。比较两组治疗后的疗效以及神经传导速度。结果观察组的治疗总有效率为94.52%,显著高于对照组的75.34%(P <0.05)。治疗后,观察组的胫神经传导速度、正中神经传导速度、腓总神经传导速度均显著快于对照组(P <0.05)。结论左卡尼汀配合甲钴胺治疗血透致尿毒症性周围神经病变疗效显著,可加快患者神经传导速度。

Objective To observe the clinical efficacy of levocarnitine combined with mecobalamine in the treatment of patients with hemodialysis-induced uremic peripheral neuropathy.Methods 146 cases of patients with hemodialysis-induced uremic peripheral neuropathy admitted to our hospital from March 2013 to March 2018 were randomly divided into two groups,with 73 cases in each group.The control group was treated with levocarnitine,while the observation group was treated with levocarnitine combined with mecobalamine.The efficacy and nerve conduction velocity after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.52%,significantly higher than 75.34%in the control group(P<0.05).After treatment,the tibial nerve conduction velocity,median nerve conduction velocity and common peroneal nerve conduction velocity in the observation group were significantly faster than those in the control group(P<0.05).Conclusions Levocarnitine combined with mecobalamine in the treatment of hemodialysis-induced uremic peripheral neuropathy has significant efficacy,and can speed up the nerve conduction velocity of patients.