摘要
Spinal cord injury will cause temporary or permanent changes in spinal cord function,leading to devastating physical,social,and vocational consequences for patients.A better understanding of the pathophysiological cascade after spinal cord injury will facilitate therapies for spinal cord injury.This research applied whole-transcriptome sequencing to analyze the rostral and caudal regions to the lesion at different time points(0 h,0.5 h,3 h,6 h,12 h,1 d,3 d,7 d,14 d,21 d,and 28 d)after hemisection of the spinal cord in rats.Differentially expressed genes between injured and sham-operated animals were identified.Significantly altered biological processes after spinal cord injury in different types of cells(astrocytes,microglia,oligodendrocytes,immune cells,and vascular endothelial cells)were enriched with these differentially expressed genes by ingenuity pathway analysis(Fig.1).
