大剂量甲氨蝶呤治疗急性淋巴细胞白血病患者实施综合护理服务的价值研究

Study on the value of high dose methotrexate in comprehensive nursing service for patients with acute lymphoblastic leukemia

目的探讨急性淋巴细胞白血病患者接受大剂量甲氨蝶呤药物治疗期间给予综合护理服务干预的可行性。方法将2017年5月至2020年3月该院收治的68例急性淋巴细胞白血病患者按数字奇偶法分为护理组和对照组,每组34例。护理组采用综合护理服务干预方式配合完成大剂量甲氨蝶呤药物治疗,对照组采用传统护理服务干预方式配合完成大剂量甲氨蝶呤药物治疗。比较两组患者IgG、IgM、IgA及诺丁汉健康调查问卷评分结果。结果护理组患者护理后IgG[(9.52±0.13)mg/mL]、IgM[(1.62±0.05)mg/mL]、IgA[(3.93±0.21)mg/mL]均明显高于对照组[分别为(8.83±0.11)、(1.33±0.03)、(1.82±0.16)mg/mL],疼痛程度评分[(73.25±6.35)分]、精力评分[(69.03±5.79)分]、睡眠质量评分[(77.03±6.79)分]、情感变化评分[(72.49±6.02)分]、躯体活动能力评分[(80.35±6.02)分]、社会生活适应能力评分[(83.15±6.49)分]均明显高于对照组[分别为(55.13±3.02)、(56.02±4.99)、(51.59±4.03)、(56.49±4.15)、(59.69±4.99)、(61.35±5.13)分],差异均有统计学意义(P<0.05)。结论有效应用综合护理服务干预方式可使急性淋巴细胞白血病患者接受大剂量甲氨蝶呤药物治疗后所获得疗效显著提升,并同时降低IgG、IgM、IgA,提升诺丁汉健康调查问卷评分,改善患者预后。

Objective To explore the feasibility of comprehensive nursing intervention in patients with acute lymphoblastic leukemia during the treatment of high dose methotrexate.Methods From May 2017 to March 2020,68 patients with acute lymphoblastic leukemia were divided into nursing group and control group according to the digital parity method,34 cases in each group.In the nursing group,the comprehensive nursing intervention was used to complete the treatment of high-dose methotrexate,while in the control group,the traditional nursing intervention was used to complete the treatment of high-dose methotrexate.Comparing the scores of IgG,IgM,IgA and Nottingham health questionnaire between the two groups.Results IgG[(9.52±0.13)mg/mL],IgM[(1.62±0.05)mg/mL],IgA[(3.93±0.21)mg/mL]in the nursing group were significantly higher than those in the control group[(8.83±0.11),(1.33±0.03),(1.82±0.16)mg/mL],pain score (73.25±6.35),energy score (69.03±5.79),sleep quality score (77.03±6.79),emotional change score (72.49±6.79),respectively The scores of physical activity(80.35±6.02)and social life adaptability(83.15±6.49)were significantly higher than those of the control group(55.13±3.02),(56.02±4.99),(51.59±4.03),(56.49±4.15),(59.69±4.99)and(61.35±5.13),respectively(P<0.05).Conclusion Effective application of comprehensive nursing intervention can significantly improve the curative effect of patients with acute lymphoblastic leukemia after receiving high-dose methotrexate,reduce IgG,IgM,IgA,improve the Nottingham Health Questionnaire score,and improve the prognosis of patients.