摘要
动脉粥样硬化(AS)作为心血管疾病(CVD)的主要病理基础,严重危害人类健康。AS实质是一种慢性炎症性疾病,抑制AS过程中的炎症反应或可成为延缓AS的关键。诸多研究已证实色素上皮衍生因子(PEDF)可通过抑制炎症反应进而延缓AS的发展,且作用机制复杂。本文就PEDF抗炎作用的机制做一综述。
Atherosclerosis(AS),as the main pathological basis of cardiovascular disease(CVD),seriously endangers human health.The essence of AS is a chronic inflammatory disease.Inhibiting the inflammatory response during AS may become the key to delay AS.Many studies have confirmed that pigment epithelium-derived factor(PEDF)can delay the development of AS by inhibiting the inflammatory response,and the mechanism of action is complex.This article reviews the mechanism of PEDF's anti-inflammatory effect.
作者
张燕
国希云
邓娴
唐果
何荆贵
朱平
Zhang Yan;Guo Xiyun;Deng Xian;Tang Guo;He Jinggui;Zhu Ping(Cadre Medical Department,the 1 st Clinical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of Geratology,the 2 nd Clinical Center,Chinese PLA General Hospital,Beijing 100853,China)
出处
《中国心血管杂志》
2020年第3期286-289,共4页
Chinese Journal of Cardiovascular Medicine
基金
军委科技委国防科技创新特区项目(17-163-15-XJ-001-004-11)
解放军总后勤部卫生部保健专项科研课题国家重点研发计划项目(2017YFC1307700)。
关键词
色素上皮衍生因子
抗炎作用
机制
动脉粥样硬化
Pigment epithelium-derived factor
Anti-inflammatory effect
Mechanism
Atherosclerosis
