月经和生育因素与肺癌风险关系的Meta分析

Menstrual and reproductive factors and lung cancer risk a Meta analysis

[目的]肺癌在女性中的发病率越来越高,其机制可能与女性雌激素表达水平较高有关,通过Meta分析探讨女性月经和生育因素与肺癌风险的关系。[方法]在Pubmed、Embase、中国知网、万方及维普数据库中搜索2020年1月15日前的相关文献。共纳入10篇符合标准的文献。应用Review Manager 5.3软件进行Meta分析。[结果]分析结果表明绝经年龄与肺癌风险没有统计学关联(RR=0.98;95%CI=0.88~1.09)。较大月经初潮年龄(>13岁)的北美女性(RR=0.95;95%CI=0.91~0.99)和较大首次活产年龄(≥30岁)的北美女性(RR=0.86;95%CI=0.76~0.98)患肺癌的风险降低。较低胎次(0~2)是北美女性患肺癌的危险因素(RR=1.07;95%CI=1.01~1.13)和亚洲女性患肺癌的保护因素(RR=0.63;95%CI=0.53~0.75)。[结论]绝经年龄与肺癌风险无相关性。较大月经初潮年龄和较大首次活产年龄的北美女性的肺癌发病率降低。较低的胎次是北美女性患肺癌的危险因素和亚洲女性患肺癌的保护因素。

[Objective]The incidence of lung cancer in women is getting higher and higher,and its mechanism may be related to the higher expression level of female estrogen.We explore the relationship between menstruation and fertility factors and female lung cancer risk through meta-analysis.[Methods]The Pubmed,Embase,CKNI,WANFANG DATA and VIP were searched by computer and the searcher deadline was Jan 15,2020.Ten articles of the standards-compliant literature were included.Review Manager 5.3 was applied for meta-analysis.[Results]The results showed there was no statistically significant association between menopausal age and lung cancer risk(RR=0.98;95%CI:0.88-1.09).Older age at menarche in North American women(>13 years old)(RR=0.95;95%CI=0.91~0.99)and older age at first live birth in North American women(≥30 y)(RR=0.86;95%CI=0.76~0.98)were associated with a significant decreased risk of lung cancer.Low parity(0-2)was a risk factor for North America female lung cancer(RR=1.07;95%CI=1.01~1.13)and a protective factor for Asia female lung cancer(RR=0.63;95%CI=0.53~0.75).[Conclusion]Age at menopause were not significantly associated with lung cancer risk.Older age at menarche in North American women and older age at first live birth in North American women were associated with a significant decreased risk of lung cancer.Low parity was a risk factor for North America female lung cancer and a protective factor for Asian female lung cancer.