氯米芬联合人绒毛膜促性腺激素治疗不孕不育的临床效果

Clinical effect of clomiphene combined with human chorionic gonadotropin on infertility

目的 探究氯米芬联合人绒毛膜促性腺激素(HCG)治疗不孕不育的临床效果.方法 选择2017年1月至2018年6月本院收治的148例初诊不孕不育女性作为研究对象,通过抽取密闭不透光信封方式分为对照组和研究组,各74例.对照组给予单纯氯米芬口服治疗,研究组则在对照组基础上给予HCG肌注治疗,5 d为1个疗程,观察3个月经周期,治疗前后B超检测卵泡直径、子宫内膜发育,比较两组患者血清黄体生成素(LH)和卵泡雌激素(FSH),随访1年观察两组患者受孕率.结果 治疗后,两组患者卵泡直径与子宫内膜厚度均升高,组内不同周期比较差异均有统计学意义(P<0.05);且研究组患者3周期卵泡直径与子宫内膜厚度均分别高于同周期对照组,组间差异均有统计学意义(P<0.05);治疗后,两组患者血清LH和FSH水平均较治疗前升高,且研究组患者第1周期治疗后LH和FSH水平明显高于对照组,组间差异有统计学意义(P<0.05);对照组和研究组患者治疗期间不良反应发生率分别为14.86%和16.22%,组间比较差异无统计学意义;对照组和研究组总受孕率分别为56.76%和83.78%,组间比较差异有统计学意义(P<0.05).结论 氯米芬联合人绒毛膜促性腺激素治疗不孕不育疗效显著,可有效提高患者LH和FSH水平,促进卵泡发育,提高受孕率,安全可靠.

Objective To investigate the clinical effect of clomiphene combined with human chorionic gonadotropin(HCG)in the treatment of infertility.Methods From January 2017 to June 2018,148 newly diagnosed infertile women admitted to our hospital were selected as study subjects.They were divided into control group and study group by extracting closed opaque envelopes,with 74 cases in each group.The control group was given oral clomiphene alone,while the research group was given HCG intramuscularly for 5 days for a course of treatment,and the menstrual cycle was observed.B-ultrasound was used to detect follicular diameter and endometrial development before and after treatment.Serum luteinizing hormone(LH)and follicular estrogen(FSH)were compared between the two groups.The pregnancy rate of the two groups was observed for 1 year.Results After treatment,the follicular diameter and endometrial thickness of the two groups of patients increased,and the differences between groups in different periods were statistically significant(P<0.05),and the follicular diameter and endometrial thickness of the patients in the study group were higher than those in the control group of the same period,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of serum LH and FSH in the two groups were higher than before treatment,and the levels of LH and FSH in the study group were significantly higher than those in the control group after the first cycle of treatment.The incidence of adverse reactions during treatment in the control group and the study group was 14.86%and 16.22%,respectively,and there was no significant difference between the groups.The total pregnancy rates of the control group and the study group were 56.76%and 83.78%,respectively,and the differences between the groups were statistically significant(P<0.05).Conclusion Clomiphene combined with human chorionic gonadotropin is effective in treating infertility.It can effectively increase the levels of LH and FSH in patients,promote the development of follicles,increase the conception rate,and is safe and reliable.