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WT1和P53及P16在低级别和高级别浆液性卵巢癌中的表达

Expression of WT1,P53 and P16 in low-grade and high-grade serous ovarian cancer
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摘要 目的 探讨WT1、P53蛋白、P16蛋白对低级别、高级别浆液性卵巢癌的鉴别诊断价值.方法 选取本院2016年7月至2019年7月收治的72例浆液性卵巢癌患者作为研究对象,依据卵巢癌组织学分级分为低级别组(n=31)与高级别组(n=41).低级别组为低级别浆液性卵巢癌,高级别组为高级别浆液性卵巢癌,对比分析WT1、P53、P16在两组中的免疫组化表达.结果 高级别组患者WT1阳性表达占比明显低于低级别组,差异有统计学意义(P<0.05);高级别组患者P53阳性表达占比高于低级别组,差异有统计学意义(P<0.05);高级别组患者P16阳性表达占比高于低级别组,差异有统计学意义(P<0.05).结论 高级别浆液性卵巢癌中P53、P16表达水平较高,而WT1表达水平较低,使用P53、P16能够诊断出高级别浆液性卵巢癌,WT1对低级别浆液性卵巢癌诊断价值较高.
作者 廖振蓉 Liao Zhenrong
出处 《当代医学》 2020年第20期125-126,共2页 Contemporary Medicine
基金 赣州市指导性科技计划(GZ2018ZSF367)。
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