妊娠前血清高水平促甲状腺激素与不良妊娠结局的关系

Relationship between high level before pregnancy of serum thyrotropin and adverse pregnancy outcome in primigravid

[目的]探索妊娠前的促甲状腺激素(TSH)水平与不良妊娠结局的关系。[方法]以我院2018年1月至2019年1月进行孕前检查且于我院有完整临床资料的283名围产期保健妇女的孕前资料为研究对象,根据妊娠结局的不同分为2组。自然流产组(n=37)为发生自然流产者,非自然流产组(n=246)为未发生自然流产者。对比2组不同程度的TSH对自然流产的影响。[结果]自然流产组的TSH水平为正常高值,占比18.92%(7/37),高于非自然流产组的7.32%(18/246);自然流产组的TSH水平为过高值,占比27.03%(10/37),大于非自然流产组的5.69%(14/246)。差异均有统计学意义(均P<0.05)。TSH水平升高发生自然流产的概率高于产前TSH水平正常者。[结论]孕前高TSH水平会增加发生不良妊娠结局的概率,应提高对孕前TSH水平的重视,加大孕前检查力度。

[Objective]To explore the relationship between thyroid stimulating hormone(TSH)level before pregnancg and adverse pregnancy outcomes in primigravid.[Methods]Retrospective analysis of our hospital from January 2018 to January 2019 pregnancy checks and we have complete clinical data of 283 in our hospital in the early maternal pregnancy data as the research object,according to different divided into two groups,the pregnancy outcome of spontaneous abortion group(n=37)for spontaneous abortion women,not spontaneous abortion group(n=246),there was no spontaneous abortion women,compared two groups of different levels of TSH effects on spontaneous abortion.[Results]Spontaneous abortion group of TSH levels for normal high value accounted for 18.92%(7/37)higher than the spontaneous abortion group(18/246),7.32%of the spontaneous abortion group of TSH level is too high value accounted for 27.03%(10/37)is greater than the spontaneous abortion group(14/246),5.69%of the differences were statistically significant(all P<0.05),the probability of spontaneous abortion TSH levels in higher prenatal maternal early TSH levels.[Conclusion]The high level of TSH before pregnancy will increase the probability of maternal adverse pregnancy outcome,so it is necessary to pay more attention to the level of TSH before pregnancy and strengthen the examination before pregnancy.