MSCT灌注成像参数对胰腺癌鉴别诊断效果及与肿瘤恶性生物学行为、微血管密度的关系

Effect of MSCT Perfusion Imaging Parameters on Differential Diagnosis of Pancreatic Cancer and Their Relationship with Malignant Biological Behavior of Tumor and Microvessel Density

本研究选取胰腺癌患者68例作为胰腺癌组,同期行手术治疗的68例急性胰腺炎患者作为胰腺炎组,探讨多层螺旋CT(MSCT)灌注成像参数:血流血容量(BV)、平均通过时间(MTT)、血流量(BF)、表面通透性(PS),对胰腺癌鉴别诊断效果及与肿瘤恶性生物学行为、微血管密度间的关系。结果表明,MSCT灌注成像参数对胰腺癌鉴别诊断有一定临床应用价值,BV、BF、PS、MTT参数值与肿瘤侵袭基因、增殖基因、微血管密度值密切相关,可为临床病情评价及预后评估提供理论依据。

In this paper,68 patients with pancreatic cancer were selected as the pancreatic cancer group,and 68 patients with acute pancreatitis who underwent surgery during the same period were selected as the pancreatitis group,the effects of multi-slice spiral CT(MSCT)perfusion imaging parameters on the differential diagnosis of pancreatic cancer and their relationship with malignant biological behavior of tumor and microvessel density were investigated.The results showed that MSCT perfusion imaging parameters have certain clinical value for the differential diagnosis of pancreatic cancer,the values of BV,BF,PS,and MTT parameters are closely related to tumor invasion genes,proliferation genes,and microvascular density values,which can provide theoretical basis for clinical condition and prognosis evaluation.