舒血宁注射液联合津力达颗粒对2型糖尿病患者血糖、血脂和炎性因子水平的影响

Effect of Shuxuening Injection combined with Jinlida Granules on levels of blood glucose,blood lipid,and inflammatory factors in patients with type 2 diabetes

目的探讨舒血宁注射液联合津力达颗粒对2型糖尿病患者血糖、血脂和炎性因子水平的影响。方法选择河南省人民医院省直第二医院2016年7月—2019年7月收治的2型糖尿病患者82例作为研究对象,将患者按照随机数字表法分为对照组和观察组,每组各41例。对照组给予津力达颗粒治疗,开水冲服,1袋/次,3次/d。观察组在对照组治疗的基础上静脉滴注舒血宁注射液,20 mL加入250 mL生理盐水。两组均治疗15 d。比较两组患者治疗前后血糖、血脂和血清炎性因子水平的变化情况。结果治疗后,两组空腹血糖(FPG)、餐后2 h血糖(2 h PG)和糖化血红蛋白(HbAlc)水平均明显降低(P<0.05),且观察组治疗后FPG和2 h PG水平显著低于对照组(P<0.05)。治疗后,两组甘油三酯(TC)、总胆固醇(TG)、低密度脂蛋白胆固醇(LDL-C)水平均明显降低(P<0.05),且观察组治疗后血脂水平显著低于对照组(P<0.05)。治疗后,两组超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤细胞坏死因子-α(TNF-α)水平均明显降低(P<0.05),且观察组血清炎性因子水平显著低于对照组(P<0.05)。结论舒血宁注射液联合津力达颗粒治疗糖尿病患者可有效的降低患者血糖、血脂水平,改善机体内炎症水平,效果显著,可在临床推广使用。

Objective To investigate the effects of Shuxuening Injection combined with Jinlida Granules on blood glucose,blood lipids,and inflammatory factor levels in patients with type 2 diabetes.Methods Patients(82 cases)with type 2 diabetes in The Second Provincial Hospital of Henan Provincial People's Hospital from July 2016 to July 2019 were divided into control and observation groups according to the random number table method,and each group had 41 cases.Patients in the control group were po administered with Jinlida Granules with warm water,1 bag/time,three times daily.Patients in the observation group were iv administered with Shuxuening Injection on the basis of control group,20 mL was added into 250 mL normal saline.Patients in two groups were treated for 15 d.The changes of blood glucose,blood lipid,and serum inflammatory factors in two groups before and after treatment were compared.Results After treatment,the levels of PFG,2 h PG,and HbAlc in two groups were significantly decreased(P<0.05),and the levels of PFG and 2 h PG in the observation group after treatment were significantly lower than those in the control group(P<0.05).After treatment,the levels of TC,TG,and LDL-C in two groups were significantly decreased(P<0.05),and the blood lipid levels in the observation group after treatment were significantly lower than those in the control group(P<0.05).After treatment,the levels of hs-CRP,IL-6,and TNF-αin two groups were significantly decreased(P<0.05).After treatment,and the serum inflammatory factors levels in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Shuxuening Injection combined with Jinlida Granules in treatment of type 2 diabetes can effectively reduce the levels of blood glucose and lipid,improve the level of inflammation,the effect is significant,can be widely used in the clinical scope.