艾迪注射液联合羟考酮治疗晚期胃癌癌痛的疗效观察

Clinical observation of Aidi Injection combined with oxycodone in treatment of cancer pain in advanced gastric cancer

目的研究艾迪注射液联合盐酸羟考酮缓释片治疗晚期胃癌癌痛的效果。方法选择2011年1月—2017年12月河南省许昌市立医院收治的58例晚期胃癌患者作为研究对象,随机将患者分为对照组和观察组,每组各29例。对照组口服盐酸羟考酮缓释片,20 mg/次,1次/d。观察组在对照组的基础上静脉滴注艾迪注射液,50 mL/次,1次/d。两组均给药7 d。观察两组治疗后的止痛效果、体力状态和不良反应发生情况。结果观察组治疗后的止痛有效率为93.10%,明显高于对照组的79.31%,两组比较差异具有统计学意义(P<0.05)。两组治疗后的体力状态均有所缓解且保持稳定,观察组患者的体力状态改善情况显著优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗期间,观察组的便秘、恶心呕吐和头晕乏力发生率均明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论艾迪注射液联合盐酸羟考酮缓释片可有效地缓解晚期胃癌患者的癌痛,降低不良反应的发生率,且能改善患者的体力状态。

Objective To investigate the clinical effect of Aidi Injection combined with Oxycodone Hydrochloride Prolonged-release Tablets in treatment of cancer pain in advanced gastric cancer.Methods Patients(58 cases)with advanced gastric cancer in Xuchang Municipal Hospital from January 2011 to December 2017 were divided into control and observation groups randomly,each group had 29 cases.Patients in the control group were po administered with Oxycodone Hydrochloride Prolonged-release Tablets,20 mg/time,once daily.Patients in the observation group were iv administered with Aidi Injection on the basis of control group,50 mL/time,once daily.Patients in two groups were treated for 7 d.After treatment,the analgesic effect,physical state,and adverse reactions in two groups were observed.Results After treatment,the effective rate of analgesia in the observation group was 93.10%,which was significantly higher than 79.31%in the control group,and the difference between two groups was statistically significant(P<0.05).After treatment,the physical state in two groups was relieved and remained stable.The improvement of the physical state in the observation group was significantly better than that in the control group,and the difference between two groups was statistically significant(P<0.05).During the treatment,the incidence of constipation,nausea and vomiting,and dizziness and fatigue in the observation group were significantly lower than those in the control group,and the difference between two groups was statistically significant(P<0.05).Conclusion Aidi Injection combined with Oxycodone Hydrochloride Prolonged-release Tablets can effectively relieve the cancer pain of patients with advanced gastric cancer,reduce the incidence of adverse reactions,and improve the physical state of patients.