枣仁安神胶囊对比苯二氮[艹卓]类治疗失眠症的Meta-分析

Meta-analysis of Zaorenanshen Capsule compared with benzodiazepines in treatment of insomnia

目的系统评价枣仁安神胶囊与苯二氮[艹卓]类药物对失眠症的临床疗效及安全性。方法检索Pubmed、the Cochrane Library、中国生物医学文献数据库(CBM)、中国学术期刊全文数据库(CNKI)、维普中文期刊全文数据库(VIP)和万方数据库中关于枣仁安神胶囊治疗失眠症的研究,检索时间自建库至2019年12月。根据纳入排除标准筛选出符合条件的随机对照试验(RCTs),采用RevMan 5.0及Stata 12.0软件进行Meta-分析。结果共纳入13篇RCTs,共计1169例。Meta-分析结果显示枣仁安神胶囊与苯二氮[艹卓]类药物治疗失眠症的临床总有效率组间差异不具有统计学意义[RR=1.01,95%CI(0.96,1.07),P=0.669];枣仁安神胶囊相比于苯二氮[艹卓]类药物可显著降低失眠症患者不良反应的发生风险,差异具有统计学意义[RR=0.19,95%CI(0.14,0.25),P=0.000]。结论应用枣仁安神胶囊与苯二氮[艹卓]类药物治疗失眠症的临床疗效相似,而枣仁安神胶囊可明显降低不良反应的发生风险。

Objective To evaluate the difference of the efficacy and safety between Zaorenanshen Capsule and benzodiazepines in the treatment of insomnia.Methods Databases including Cochrane Library,PubMed,CBM,CNKI,VIP and Wanfang Database were searched to collect randomized controlled trials(RCTs)about Zaorenanshen Capsule treatment of insomnia from the inception to December 2019.Meta-analysis was performed by RevMan 5.0 software and Stata 12.0 software.Results A total of 13 RCTs,and 1169 patients were included.The result of meta-analysis showed that,no significant difference was showed in the total effective rate between Zaorenanshen Capsule and benzodiazepines[RR=1.01,95%CI(0.96,1.07),P=0.669],while Zaorenanshen Capsule significantly reduced the risk of adverse reactions in patients with insomnia compared with benzodiazepines[RR=0.19,95%CI(0.14,0.25),P=0.000].Conclusion The efficacy of Zaorenanshen Capsule and benzodiazepine was similar in the treatment of insomnia,while Zaorenanshen Capsule can significantly reduce the risk of adverse reactions.