摘要
注射用丹参多酚酸(SAFI)作为脑梗死的辅助治疗药,能有效改善神经功能缺损症状,有效性和安全性已经得到认可。近年研究发现SAFI在神经系统疾病中具有抗炎、抑制氧化应激、抑制神经细胞凋亡、拮抗缺血再灌注损伤、稳定斑块、改善认知功能等作用。就近年来国内外对SAFI在中枢神经系统疾病中的药理作用的研究进展进行综述,为进一步深度研发和临床合理应用提供依据。
As an adjuvant therapy for cerebral infarction,Salvianolic Acid for Injection(SAFI)can effectively improve the symptoms of neurological deficit,and its efficacy and safety have been recognized.In recent years,studies have found that SAFI has the functions of anti-inflammatory,inhibiting oxidative stress,regulating apoptosis,antagonizing ischemia-reperfusion injury,stabilizing plaques,and improving cognitive in neurological diseases.In this paper,the research progress of the pharmacological effects of SAFI in central nervous system diseases at home and abroad are reviewed in recent years,providing a basis for further research and development and rational clinical application.
作者
顾文
王荔
GU Wen;WANG Li(Shanxi Medical University,Taiyuan 030000,China;Department of Neurology,The Second Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《药物评价研究》
CAS
2020年第6期1183-1188,共6页
Drug Evaluation Research
基金
山西省自然科学基金(201801D121219)。
关键词
注射用丹参多酚酸
神经系统
脑卒中
炎性反应
氧化应激
细胞凋亡
Salvianolic Acid for Injection
nervous system
stroke
inflammatory response
oxidative stress
apoptosis
