TACE对原发性肝癌患者的疗效及NLR、PLR的影响研究

Effect of TACE on the efficacy and NLR and PLR of patients with primary liver cancer

目的 研究经导管动脉化疗栓塞(TACE)对原发性肝癌患者的疗效及中性粒细胞/淋巴细胞计数比(NLR)、血小板/淋巴细胞计数比(PLR)的影响.方法 选择2015年6月~2019年1月我院接诊的原发性肝癌患者80例作为研究对象,采用随机数表法将患者分为两组,每组各40例.对照组予传统肝切除术治疗,观察组采用TACE治疗.对比两组治疗后的临床效果,NLR、PLR、癌胚抗原(CEA)、可溶性B7-H4、可溶性白细胞介素-2受体(sIL-2R)及并发症发生情况.结果 治疗后,两组患者的总有效率分别为75.00%和52.50%,观察组高于对照组,差异有统计学意义(P<0.05);治疗前,两组患者NLR、PLR水平对比,差异无统计学意义(P>0.05);治疗后,患者NLR、PLR水平下降,观察组低于对照组,差异有统计学意义(P<0.05);治疗前,两组患者CEA、B7-H4、sIL-2R水平对比,差异无统计学意义(P>0.05);治疗后,两组患者CEA、B7-H4、sIL-2R水平下降,观察组低于对照组,差异有统计学意义(P<0.05);两组患者并发症发生率分别为17.50%、40.00%,观察组低于对照组,差异有统计学意义(P<0.05).结论 在原发性肝癌患者中使用TACE效果显著,可有效改善患者肿瘤标志物水平,减少并发症,值得推广应用.

Objective To study the effect of transcatheter arterial chemoembolization(TACE)on the outcome of patients with primary liver cancer and the ratio of neutrophil/lymphocyte count(NLR)and platelet/lymphocyte count ratio(PLR).Methods 80 patients with primary liver cancer who were admitted to our hospital from June 2015 to January 2019 were enrolled.The patients were divided into two groups according to random number table method,with 40 patients in each group.The control group was treated with conventional hepatectomy and the observation group was treated with TACE.The clinical effects,NLR,PLR,carcinoembry antigen(CEA),soluble B7-H4,soluble interleukin-2 receptor(sIL-2R)and complications after treatment were compared.Results After treatment,the excellent and good rate of the two groups were 75.00%and 52.50%,respectively.The excellent and good rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in NLR and PLR levels between the two groups(P>0.05).After treatment,the patients'NLR,PLR levels decreased.The NLR,PLR levels of the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in CEA,B7-H4,sIL-2R between two groups before treatment(P>0.05).After treatment,the levels of CEA,B7-H4 and sIL-2R decreased,and the levels of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).The incidence of complications in the two groups was 17.50%and 40.00%,respectively.The incidence of complications of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The use of TACE in patients with primary liver cancer has significant effect,which can effectively improve the level of tumor markers and reduce complications.It is worthy of popularization and application.