RDW-SD、RDW-CV、PDW、EOS%与支气管哮喘儿童肺功能的相关性研究

Correlation between RDW-SD,RDW-CV,PDW,EOS%and lung function in children with asthma

目的探讨红细胞分布宽度标准差(RDW-SD)、红细胞分布宽度变异系数(RDW-CV)、血小板分布宽度(PDW)、嗜酸性粒细胞(EOS%)与支气管哮喘儿童基础肺功能各指标及支气管舒张试验后各指标改善率的相关性研究。方法选择2018年1月—2019年4月于北京市东城区妇幼保健计划生育服务中心儿科门诊就诊,经临床明确诊断支气管哮喘,处于非急性期,且完成舒张试验测定的患儿72例,收集并记录初诊时血常规和基础肺功能及支气管舒张试验检查结果。分析RDW-SD、RDW-CV、PDW、EOS%与基础肺功能各指标及支气管舒张试验后各指标改善率的相关性。结果RDW-SD、RDW-CV、PDW、EOS%与基础肺功能各指标,用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、1秒率(FEV1/FVC)、呼气峰值流量(PEF)、用力呼出25%肺活量时的瞬间流量(FEF25)、用力呼出50%肺活量时的瞬间流量(FEF50)、用力呼出75%肺活量时的瞬间流量(FEF75)、最大呼气中期流量(MMEF)均无明显相关性(P>0.05);RDW-SD与支气管舒张试验后FEV1、FEV1/FVC、PEF、FEF25、MMEF改善率呈正相关(P<0.05),其中与PEF改善率的相关性最显著(R=0.299,P=0.011),与FVC、FEF50、FEF75改善率无相关性(P>0.05)。RDW-CV、PDW、EOS%与支气管舒张试验后FVC、FEV1、FEV1/FVC、PEF、FEF25、FEF50、FEF75、MMEF改善率均无相关性(P>0.05)。结论RDW-SD与支气管舒张试验后FEV1、FEV1/FVC、PEF、FEF25、MMEF改善率呈正相关,其中与PEF改善率的相关性最显著,可作为评估哮喘儿童气道可逆性的一个操作简单、廉价、良好的参考指标。

Objective To investigate correlation between RDW-SD,RDW-CV,PDW,EOS%and basic lung function indexes of children with asthma and improvement rate of indexes after bronchodilation test.Methods From January 2018 to April 2019,totally 72 children patients diagnosed with asthma were included from maternal and child health care family planning service center,who were inthe non-acute stage and completed the diastolic test.blood routine and basic pulmonary function and bronchodiastolic test results were collected and recorded.Before and after bronchial dilatation tests,the correlation of RDW-SD,RDW-CV,PDW and EOS%with basic pulmonary function indexes and improvement rate after diastolic test was analyzed.Results There was no significant correlation between RDW-SD,RDW-CV,PDW,EOS%and basic pulmonary function indexes,such as FVC,FEV1,FEV1/FVC,PEF,FEF25,FEF50,FEF75,MMEF(P>0.05);RDW-SD was positively correlated with FEV1,FEV1/FVC,PEF,FEF25 and MMEF of improvement rate after bronchial dilatation test(P<0.05),the correlation with PEF of improvement rate was the most significant(R=0.299,P=0.011),there was no correlation with the improvement rate of FVC,FEF50 and FEF75(P>0.05).RDW-CV,PDW,EOS%were not irrelevant to the improvement rate of FVC,FEV1,FEV1/FVC,PEF,FEF25,FEF50,FEF75 and MMEF after the broncholic test(P>0.05).Conclusion RDW-SD was positively correlated with FEV1,FEV1/FVC,PEF,FEF25 and MMEF of improvement rate after bronchial dilatation test,the correlation with PEF of improvement rate was the most significant,RDW-SD may be a simple,inexpensive and good reference indicator for predicting airway reversibility in children with asthma.