高压氧联合醒脑静对CO中毒患者心肌损伤及CRP、ALT水平的影响

Effect of high pressure oxygen combined with Xingnaojing on myocardial damage and CRP,ALT levels in patients with CO poisoning

目的研究高压氧联合醒脑静对一氧化碳(CO)中毒患者心肌损伤及C反应蛋白(CRP)、谷丙转氨酶(ALT)水平的影响。方法将2017年10月—2019年8月安阳市第三人民医院收治的60例CO中毒患者依据随机数表法分为对照组和观察组,每组30例。对照组使用高压氧治疗,观察组在对照组基础上加用醒脑静治疗。对比分析两组患者治疗前后心肌损伤标志物变化。研究两组患者炎症因子、肝功能改善情况。结果治疗2周后,两组患者CK-MB、cTnI、CK、CRP、ALT水平均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。结论高压氧联合使用醒脑静治疗CO中毒,能够改善患者炎症反应,有效缓解心脏和肝脏功能损伤,利于预后良好发展。

Objective To study the effect of high pressure oxygen combined with Xingnaojing on myocardial damage and C-reactive protein(CRP),alanine aminotransferase(ALT)levels in patients with carbon monoxide(CO)poisoning.Methods Totally 60 patients with CO poisoning who admitted in the hospital from October 2017 to August 2019 were divided into control group and observation group according to random number table,with 30 cases in each group.Control group was treated with high pressure oxygen,and observation group was given Xingnaojing based on control group.The changes of myocardial damage indexes before and after treatment were compared between two groups.The inflammatory factors,improvement of liver function in two groups were observed.Results After treatment for 2 weeks,the levels of CK-MB,cTnI,CK,CRP,ALT in two groups decreased,and observation group was lower than that of the control group(P<0.05).Conclusion High pressure oxygen combined with Xingnaojing in treatment of CO poisoning can improve inflammatory response,relieve cardiac and hepatic function injury,and promote better prognostic development.