蛋白质组学在糖尿病及其并发症中的应用

Application of proteomics in diabetes and its complications

蛋白质组学是近年来兴起的研究各种疾病的最前沿领域和热点之一,蛋白组学的发展为糖尿病早期诊断及治疗提供了新的研究方向并取得一定的研究成果,糖尿病早期诊断有助于控制患者的病情发展甚至免于手术治疗,对于改善患者预后具有重要意义。本文从蛋白质组学研究技术及其在糖尿病及并发症中应用的现状和前景进行了总结,就蛋白质组学的快速发展对糖尿病研究的影响以及在发现更多糖尿病生物标志物方面的积极作用进行了展望,未来的研究应更加注重发现生物标志物之间的相互联系,为糖尿病及其并发症的诊断与治疗提供新的思路。

Proteomics is one of the most advanced fields and hotspots in the research of various diseases in recent years.Its development has provided a new research direction for the early diagnosis and treatment of diabetes and has achieved some research results.Early diagnosis is helpful to control the progression of the disease or even avoid surgical treatment,which is of great significance for improving the prognosis of patients.This paper reviews the current status and prospects of proteomic technology and its applications in diabetes as well as its complications with a prospect of the impact of the rapid development of proteomics on diabetes and its positive role in discovering more diabetes biomarkers.In the future research,more attention should be paid to the interconnections between biomarkers.