ADC值对食管癌T分期及病理分级的诊断价值

The value of ADC value in T staging and histologic differentiation grade of esophageal cancer

目的探讨ADC值与食管癌T分期及病理分级的关系。材料与方法收集经病理证实的初诊食管癌患者,术前均行常规MRI及弥散加权成像(diffusion weighed imaging,DWI)扫描,根据食管癌MRI分期、病理分级、有无淋巴结转移等进行分组,测量食管癌原发灶的平均ADC值,对其与MRI分期、病理分级、有无淋巴结转移的相关性进行统计分析。结果食管癌平均ADC值与T分期呈负相关(r=-0.645,P<0.01),随着肿瘤T分期的增加,ADC值呈逐渐减小趋势。低分化组平均ADC值小于中-高分化组,中-高组平均ADC值为(1.8514±0.40295)×10^-3 mm^2/s,低分化组患者平均ADC值为(1.7125±0.37767)×10^-3 mm^2/s,不同分化程度两组间平均ADC值差异不具有统计学意义(P=0.683)。结论ADC值对食管癌T分期有重要意义,可以在术前或是综合治疗之前为临床对肿瘤分期及分化程度预测提供量化指标,从而为临床治疗提供帮助。

Objective:To analyze the correlation with T stage,histologic differentiation grade of esophageal cancer.Materials and Methods:A total of 45 pathologically confirmed patients with esophageal cancer were included.Mean tumor apparent diffusion coefficient(ADC)for different histologic differentiation grades,T-stages were measured and compared.Results:The average ADC value of esophageal cancer was negatively correlated with the T staging,and the ADC value decreased with the increase of T staging.The results of Spearson correlation analysis showed that average ADC value was negatively correlated with T stage(r=-0.645,P<0.01).The average ADC value of the low-differentiation group was lower than that of the medium-high differentiation group(1.8514±0.40295)×10^-3 mm^2/s,1.7125±0.37767)×10^-3 mm^2/s).There were no significant differences in ADC value no matter what kind of histological grade.Conclusions:DWI was useful for evaluating T stage of esophageal cancer,and can reflect the clinical T stage of esophageal cancer,providing help for clinical treatment.