生物制剂对类风湿性关节炎患者血脂水平影响的研究进展

Research progress in the effect of biological agents on blood lipid levels in patients with rheumatoid arthritis

加速的动脉粥样硬化在类风湿性关节炎(Rheumatoid arthritis,RA)患者的心血管疾病中起关键作用,导致RA患者比一般人群死亡率更高。血脂的异常和炎性细胞因子的增加可能是这些患者在动脉粥样硬化过程早期出现内皮功能障碍的主要原因,生物制剂已问世多年,是治疗RA的关键性药物,但其对RA患者血脂的影响还存在争议,本文归纳了常见生物制剂对RA患者脂质谱的影响,提示临床医生应更加关注RA患者的血脂管理。

Accelerated atherosclerosis plays a key role in cardiovascular disease in patients with rheumatoid arthritis(RA),leading to higher mortality in RA patients than in the general population.Abnormal blood lipids and increased inflammatory cytokines may be the main reason for endothelial dysfunction in these patients at the early stage of atherosclerosis.Biological agents have been available for many years and are the key drugs for treating RA,but there impacts on blood lipids in RA patients are still controversial.This article summarizes the effects of common biological agents on lipid mass spectra in RA patients,suggesting that clinicians should pay more attention to lipid management in RA patients.