Sirt1治疗后发性白内障的研究进展

The research advances of Sirt1 in the treatment of posterior capsular opacification

Sirt1是sirtuin家族中研究较为广泛和深入的成员。Sirt1如交通枢纽一般,连接上游microRNA及下游各种转录因子,在抗衰老、细胞凋亡、氧化应激和DNA损伤方面发挥显著作用。后发性白内障(posterior capsular opacification,PCO)是导致白内障患者术后视力下降最常见的并发症。目前国内外研究尚未有Sirt1对PCO的发生发展的体内、外相关研究。本文综述了Sirt1生物学作用的主要路径以及Sirt1在后发性白内障治疗中的前景展望。

Sirt1 is an extensive and in-depth member of the sirtuin family.Like a transportation hub,it connects upstream microRNA and various downstream transcription factors,and plays an important role in anti-aging,cell apoptosis,oxidative stress and DNA damage.Posterior capsular opacification(PCO)is the most common complication of postoperative visual acuity loss in cataract patients.At present,there are no in vivo and in vitro studies on the occurrence and development of PCO by Sirt1.This article provides a review on the main pathways of biological action of Sirt1 and the prospect of Sirt1 in the treatment of PCO.