摘要
本文主要介绍临床试验中非劣效性检验的概念、原理和作用以及成组设计一元定量资料非劣效性检验的SAS实现。通过实例展示SAS在非劣效性检验中的应用,分别基于原始的定量数据或者基于给定样本含量、均数、标准差两种数据结构下进行操作,对结果进行解释并作出结论。
This article mainly introduced the concept,principle and function of noninferiority testing in clinical trials and the implementation of SAS for noninferiority testing of unary quantitative data in group design.The application of SAS software in the noninferiority testing was demonstrated through examples.The operation was based on the original quantitative data or the data structure of the given sample size,mean,and standard deviation.And it was also to explain the results and make conclusions.
作者
陈阳
刘媛媛
李长平
胡良平
Chen Yang;Liu Yuanyuan;Li Changping;Hu Liangping(Department of Epidemiology and Health Statistics,School of Public Health,Tianjin Medical University,Tianjin 300070,China;Specialty Committee of Clinical Scientific Research Statistics of World Federation of Chinese Medicine Societies,Beijing 100029,China;Graduate School,Academy of Military Sciences PLA China,Beijing 100850,China)
出处
《四川精神卫生》
2020年第3期226-230,共5页
Sichuan Mental Health
基金
国家自然科学基金项目(项目名称:贝叶斯生存分析方法在肝细胞癌肝移植患者预后预测中的应用研究,项目编号:81803333)。
关键词
非劣效检验
非劣效性界值
T检验
算数均数比较
Noninferiority testing
Noninferiority limit value
t test
Comparison of arithmetic mean
