帕瑞昔布钠联合盐酸羟考酮对腹腔镜患者术后恢复质量和炎症反应的影响

Effect of parecoxib sodium combined with oxycodone on postoperative recovery quality and inflammation of patients undergoing laparoscopy

目的比较帕瑞昔布钠与盐酸羟考酮联合使用对腹腔镜患者术后恢复质量和炎症反应的影响。方法收集2017~2019年徐州医科大学附属医院86例行择期腹腔镜手术的患者随机分为帕瑞昔布钠组(P组)及生理盐水组(C组)。所有患者在术毕前30 min均注射盐酸羟考酮注射液0.1 mg/kg,P组患者静脉予以帕瑞昔布钠1.0 mg/kg,C组患者注射等体积生理盐水。采用视觉模拟评分法(VAS)评估患者术后疼痛情况,恢复质量(QoR-40)量表评估术后24 h恢复质量评分,记录患者术后炎性反应、平均住院时间等指标。结果两组患者一般资料比较差异均无统计学意义(P>0.05)。P组患者术后C反应蛋白(CRP)浓度明显低于C组(P<0.05)。P组患者术后24 h QoR-40总评分、身体舒适度及情绪状态模块评分高于C组(P<0.05)。在术后6、12 h,两组患者VAS评分比较差异有统计学意义(P<0.05)。P组患者的平均住院时间短于C组患者(P<0.05)。结论帕瑞昔布钠静脉注射可增强盐酸羟考酮的镇痛作用,改善恢复质量、降低患者术后炎症反应。

Objective To compare the effects of parecoxib sodium combined with oxycodone hydrochloride on postoperative recovery quality and inflammatory response in patients undergoing elective laparoscopic surgery.Methods 86 patients undergoing elective laparoscopic surgery were randomly divided into Parecoxib Sodium group(group P)and normal saline group(group C).At about 30 minutes before the end of surgery,oxycodone hydrochloride(0.1 mg/kg)was injected for all patients.The patients in group P were administered intravenous parecoxib sodium(1.0 mg/kg),while patients in group C were injected with an equal volume of normal saline.The visual analogue scale/score(VAS)was used to evaluate the postoperative pain.The quality of recovery scale(QoR-40 scale)was used to evaluate the postoperative recovery quality.The postoperative inflammatory response and average length of hospitalization were also recorded.Results The level of CRP in group P was significantly lower than that in group C(P<0.05).The total score of QoR-40,and the score of the physical comfort and emotional state in group P were higher than those in group C(P<0.05).There were no significant difference in general information between the two groups(P>0.05).There were statistically significant difference in the VAS score between the two groups of patients at 6 and 12 hours after surgery(P<0.05).The average length of hospitalization in group P were shorter than that in group C,and the difference was statistically significant(P<0.05).Conclusion Intravenous injection of parecoxib sodium can enhance the analgesic effect of oxycodone hydrochloride,improve the quality of recovery after laparoscopic surgery,and reduce postoperative inflammatory reactions.