阿司匹林对老年脑梗死患者预防再梗死的疗效和安全性研究

Efficacy and safety of aspirin in prevention of re-infarction in elderly patients with cerebral infarction

目的 探讨阿司匹林对老年脑梗死患者预防再梗死的疗效和用药安全性.方法 117例老年脑梗死稳定期患者作为研究对象,依据随机数字表法分为对照组(58例)和实验组(59例).两组均相应控制血压、血糖、血脂,实验组给予口服阿司匹林治疗,对照组不服用阿司匹林,均观察12个月.比较两组再梗死及出血事件发生率;实验前后两组血压、血糖、血脂达标率.结果 实验组出血发生率15.52%高于对照组的1.82%,差异有统计学意义(P<0.05).实验组与对照组脑梗死再梗死率分别为5.17%、3.64%,比较差异无统计学意义(P>0.05).试验后,两组血压、血糖、血脂达标率组内比较差异有统计学意义(P<0.05),组间比较差异无统计学意义(P>0.05).结论 对于血压、血脂、血糖控制良好的老年脑梗死患者,阿司匹林对预防脑梗死再梗死的疗效差异不显著,出血风险差异显著,临床应用安全性需要关注.

Objective To discuss the efficacy and medication safety of aspirin in prevention of re-infarction in elderly patients with cerebral infarction.Methods A total of 117 elderly patients with cerebral infarction as study subjects were divided into control group(58 cases)and experimental group(59 cases)by random numerical table.The blood pressure,blood glucose and blood lipid were controlled in both groups.The experimental group was treated with oral aspirin,while the control group was not treated with aspirin,and all were observed for 12 months.The incidence of re-infarction and bleeding,standard-reaching rate of blood pressure,glucose and lipid before and after experiment were compared between the two groups.Results The incidence of bleeding 15.52%of the experimental group was higher than that of the control group 1.82%,and the difference was statistically significant(P<0.05).The incidence of re-infarction of the experimental group and control group were 5.17%and 3.64%,and the difference was not statistically significant(P>0.05).After experiment,the standardreaching rate of blood pressure,blood glucose and blood lipid of the two groups were higher than those before experiment,and the difference was statistically significant(P<0.05).After experiment,there was no statistically significant difference in standard-reaching rate of blood pressure,glucose and lipid between the two groups(P>0.05).Conclusion For the elderly patients with cerebral infarction who have good control of blood pressure,blood lipid and blood glucose,there is no significant difference in the effect of aspirin on the prevention of reinfarction of cerebral infarction,but there is a significant difference in the risk of bleeding.The safety of clinical medication needs extra attention.