慢性阻塞性肺疾病中的T淋巴细胞

T lymphocytes in chronic obstructive pulmonary disease

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一种以持续的呼吸道症状和气流受限为特征的疾病,接触香烟烟雾是其主要的危险因素。目前公认慢性炎症反应是COPD发病的主要机制。COPD的免疫病理基础包括慢性吸烟引起的先天性免疫反应和适应性免疫反应。既往研究多集中于以中性粒细胞和巨噬细胞浸润为主的固有免疫反应,近年来,越来越多证据表明以T细胞为主的适应性免疫反应参与了COPD的发生和发展。

Chronic obstructive pulmonary disease(COPD) is a disease characterized by persistent respiratory symptoms and restricted airflow, and exposure to cigarette smoke is the main risk factor. Chronic inflammatory response is currently recognized as the main pathogenesis of COPD. The immunopathological basis of COPD includes congenital and adaptive immune responses induced by chronic smoking. Previous studies have focused on the innate immune response dominated by neutrophil and macrophage infiltration. In recent years, more and more evidence has shown that the adaptive immune response dominated by T cells is involved in the occurrence and development of COPD.