安列克治疗宫缩乏力性产后出血的疗效与安全性

Efficacy and safety of anilek in the treatment of postpartum hemorrhage due to uterine inertia

目的研究安列克治疗宫缩乏力性产后出血的疗效及安全性。方法选择临汾市妇幼保健院2016年1月至2018年12月收治的宫缩乏力性产后出血患者70例作为研究对象,按照随机数字表法分为米索前列醇组与安列克组,每组35例。米索前列醇组采取米索前列醇片治疗,安列克组采取安列克肌肉注射或宫体注射治疗,对两组患者的临床效果进行评价,并记录产后2、24 h的出血量及不良反应发生情况。结果安列克组患者止血总有效率(94.29%,33/35)高于米索前列醇组(82.86%,29/35),P<0.05;安列克组产后2、24 h出血量依次为(204.34±33.21)、(266.54±52.10)ml,均少于米索前列醇组的(345.29±29.48)、(401.48±55.48)ml,两组比较差异有统计学意义(P<0.05);两组患者均有不良反应发生,但组间比较差异未见统计学意义(P>0.05)。结论宫缩乏力性产后出血患者采用安列克治疗可取得不错的临床效果,而且安全性高,同时可减少产后出血量。

Objective To study the efficacy and safety of anilek in the treatment of postpartum hemorrhage due to uterine inertia.Methods A total of 70 patients with postpartum hemorrhage due to uterine inertia admitted to Linfen Maternal and Child Health Hospital from January 2016 to December 2018 were enrolled in the study.The patients were divided into misoprostol group and anilek group by the random number table method,with 35 cases in each group.The patients in misoprostol group were treated with misoprostol,the patients in anilek group were treated with intramuscular or intrauterine injection of anilek.The clinical effects of the two groups were evaluated,and the amount of bleeding and adverse reactions were recorded at 2 and 24 h after delivery.Results The total effective rate of hemostasis of the patients in the anilek group(94.29%,33/35)was significantly higher than that in the misoprostol group(82.86%,29/35),P<0.05.The bleeding volumes of anilek group at 2 and 24 h after delivery were(204.34±33.21)ml and(266.54±52.10)ml,respectively,which were lower than the(345.29±29.48)ml and(401.48±55.48)ml in the misoprostol group,and the difference between the two groups was statistically significant(P<0.05).Both groups had adverse reactions,but there was no significant difference in the incidence of adverse reaction between the two groups(P>0.05).Conclusions Using anilek in the treatment of postpartum hemorrhage due to uterine inertia can achieve good clinical results and reduce the amount of postpartum hemorrhage,with high safety.