奥沙利铂与紫杉醇分别联合5-氟尿嘧啶化疗方案在胃癌根治术后的应用效果比较

Comparison of efficacy of oxaliplatin versus paclitaxel in combination with 5-fluorouracil chemotherapy in patients with gastric cancer after radical operation

目的比较分析奥沙利铂+5-氟尿嘧啶、紫杉醇+5-氟尿嘧啶应用于胃癌根治术后的化疗价值。方法抽取2014年1月至2016年7月河南科技大学第一附属医院收治的150例胃癌根治术患者作为研究对象,经随机数字表法将其分为研究组(75例)与对照组(75例)。两组胃癌患者均行根治性手术治疗,研究组胃癌根治术后行奥沙利铂联合5-氟尿嘧啶化疗,对照组胃癌根治术后行紫杉醇化疗5-氟尿嘧啶化疗。记录两组远期疗效、化疗药物相关不良反应发生情况、生活质量变化情况。结果两组无进展生存时间比较,差异未见统计学意义(P>0.05),两组疾病复发率、无瘤生存率、转移率、死亡率比较,差异未见统计学意义(P>0.05);研究组化疗药物相关骨髓抑制(25.33%)、丙氨酸氨基转移酶升高(1.33%)所占比例均低于对照组(分别为49.33%、9.33%),差异未见统计学意义(P>0.05);两组其他化疗药物相关不良反应发生情况比较,差异未见统计学意义(P>0.05);两组化疗前WHOQOL-100量表评分比较,差异未见统计学意义(P>0.05);化疗后研究组WHOQOL-100量表评分与化疗前比较,差异未见统计学意义(P>0.05);化疗后对照组WHOQOL-100量表评分低于化疗前(P<0.05)。结论胃癌根治术后应用奥沙利铂+5-氟尿嘧啶、紫杉醇+5-氟尿嘧啶化疗方案疗效均较优,但前者安全性较为理想,有利于保障患者生活质量。

Objective To compare and analyze the chemotherapy value of oxaliplatin + 5-fluorouracil and paclitaxel + 5-fluorouracil after radical gastrectomy.Methods A total of 150 patients with gastric cancer who underwent radical gastrectomy in the First Affiliated Hospital of Henan University of Science and Technology from January 2014 to July 2016 were divided into study group (n=75) and control group (n=75). The patients in study group received oxaliplatin + 5-fluorouracil chemotherapy and the patients in control group received paclitaxel + 5-fluorouracil chemotherapy. The long-term effect, adverse reactions and quality of life of the two groups were recorded.Results The progression free survival time was compared between the two groups, the difference was not statistically significant (P>0.05);the recurrence rate, tumor free survival rate, metastasis rate and mortality were compared between the two groups, the differences were not statistically significant (P>0.05);chemotherapy drug-related myelosuppression (25.33%) and elevation of alanine aminotransferase (1.33%) in study group were lower than those in control group (49.33%, 9.33%), the differences were not statistically significant (P>0.05);adverse reactions of other chemotherapy drugs between the two groups were compared, the differences were not statistically significant (P>0.05);WHOQOL-100 scores were compared between the two groups before chemotherapy, the differences were not statistically significant (P>0.05);the score of WHOQOL-100 in the control group after chemotherapy was significantly lower than that before chemotherapy (P<0.05).Conclusions Chemotherapy with oxaliplatin + 5-fluorouracil and paclitaxel + 5-fluorouracil is effective after radical gastrectomy for gastric cancer, but the former is safe and beneficial to the quality of life of patients.