摘要
熊果酸(Ursolic acid,UA)是一种主要存在于大多数植物中的天然化合物,前期实验研究发现UA通过调节多条信号通路、抑制氧化应激、诱导肝星状细胞(Hepatic stellate cell,HSC)凋亡,改善肠道粘膜屏障,进而促进肝小叶中央区坏死肝细胞修复,从而起到抗肝纤维化的作用。为更好开发利用UA,文章就UA抑制肝纤维化的作用及其机制展开论述。
Ursolic acid(UA)is a kind of natural compound mainly existing in most plants.Previous studies found that UA can regulate multiple signal pathways,inhibit oxidative stress and induce hepatic stellate cells(HSC)apoptosis,improve intestinal mucosal barrier,and then promote the repair of necrotic hepatocytes in the central area of liver lobule,so as to play an anti fibrosis role.In order to make better use of UA,this paper discusses the role and mechanism of UA in inhibiting liver fibrosis.
出处
《大众科技》
2020年第5期33-36,共4页
Popular Science & Technology
基金
广西高校中青年教师科研基础能力提升项目(2019KY0351)。
关键词
熊果酸
肝纤维化
作用机制
研究进展
ursolic acid
liver fibrosis
mechanism of action
research progress
