小剂量右美托咪定用于无痛胃镜检查临床评价

Clinical Evaluation of Low-Dose Dexmedetomidine for Painless Gastroscopy

目的探讨无痛胃镜检查中应用小剂量右美托咪定的效果。方法选取随州市中心医院2018年实施无痛胃镜检查的患者100例,按随机数字表法分为研究组和对照组,各50例。两组患者均采用丙泊酚+舒芬太尼实施麻醉。麻醉前,研究组患者静脉泵注0.3μg/kg盐酸右美托咪定注射液,对照组患者静脉泵注等体积0.9%氯化钠注射液。结果研究组患者给药麻醉后(T1)、检查中(T2)、检查结束时(T3)的平均动脉压均明显高于对照组(P <0.05);研究组患者T1,T2时的心率明显高于对照组(P <0.05),T3时显著低于对照组(P <0.05);研究组患者术后30,60,120 min的疼痛评分(VAS评分)均明显低于对照组(P <0.05);研究组麻醉效果明显优于对照组(P <0.05);研究组不良反应发生率为12.50%,明显低于对照组的30.00%(P <0.05)。结论无痛胃镜检查中应用小剂量右美托咪定,有利于维持患者血流动力学稳定,减轻术后疼痛,减少不良反应,提升麻醉效果。

Objective To explore the effect of low-dose dexmedetomidine(Dex)in painless gastroscopy.Methods A total of 100 patients with painless gastroscopy in 2018 in the hospital were selected and divided into the study group and control group according to random number table method,50 cases in each group.The two groups were treated with propofol+sufentanil for anesthesia.Before anesthesia,the study group was injected 0.3μg/kg Dex intravenously;the control group received the same amount of 0.9%sodium chloride injection via intravenous injection pump.Results The mean arterial pressure of the study group after anesthesia administration(T1),during examination(T2),and at the end of the examination(T3)were significantly higher than those in the control group(P<0.05).The heart rates of the study group at T1,T2 were significantly higher than those in the control group(P<0.05),and significantly lower than that in the control group at T3(P<0.05).The visual analog scale(VAS)scores of the study group at 30,60,120 min postoperatively were significantly lower than those of the control group(P<0.05).The anesthesia effect of the study group was significantly better than the control group(P<0.05).The incidence of adverse reactions in the study group was 12.50%,which was significantly lower than 30.00%in the control group(P<0.05).Conclusion The application of low-dose Dex in painless gastroscopy is beneficial to maintain the patient’s hemodynamic stability,reduce postoperative pain,reduce adverse reactions,and improve the anesthetic effect.