低分子肝素联合口服补液盐在临界性羊水过少中的治疗效果

Clinical efficacy of Low molecular weight heparin combined with Oral Rehydration salts on critical amniotic fluid oligohydramnios

目的探讨低分子肝素联合口服补液盐对临界性羊水过少的临床效果。方法选取2018年10月~2019年1月浙江省金华市中心医院彩超检查羊水指数(AFI)为5~8 cm的孕妇68例,依据随机数字表法,将其分为观察组(36例)和对照组(32例)。观察组予低分子肝素、口服补液盐Ⅲ治疗;对照组不做处理,临床观察。7 d后比较两组AFI、脐动脉收缩期最大血流/脐动脉舒张期末血流值变化(S/D),统计两组自然分娩率、足月产率、新生儿窒息发生率、产后出血发生率。结果治疗后观察组AFI高于治疗前,S/D值低于治疗前;且观察组AFI值高于对照组,S/D值低于对照组,差异均有统计学意义(均P <0.05);对照组AFI及S/D值与治疗前比较,差异无统计学意义(P>0.05)。观察组自然分娩率、足月产率高于对照组,差异有统计学意义(P <0.05);两组新生儿窒息和产后出血发生率比较,差异无统计学意义(P> 0.05)。结论低分子肝素联合口服补液盐对临界性羊水过少有效。

Objective To study the clinical efficacy of low molecular weight heparin combined with Oral Rehydration Salts on critical amniotic fluid oligohydramnios.Methods From October 2018 to January 2019,68 pregnant women with amniotic fluid index(AFI)between 5-8 cm were selected for color Doppler ultrasound examination in Jinhua Municipal Central Hospital of Zhejiang Province.According to the random number table method,they were divided into the observation group(36 cases)and the control group(32 cases).The observation group was treated with Low molecular weight heparin and Oral Rehydration SaltⅢand the control group was given clinical observation without treatment.The changes of AFI and ratio of end systolic peak/end diastolic peak(S/D)in the two groups were observed after treatment for 7 d.Natural delivery rate,full-term birth rate,the incidence of neonatal asphyxia and postpartum hemorrhage in the two groups were counted.Results AFI values of the observation group after treatment were higher than those of the control group,S/D values were lower than those of the control group,and AFI values of the observation group were higher than those of the control group,S/D values were lower than those of the control group,and the differences were statistically significant(all P<0.05).AFI and S/D values in the control group were not significantly different from those before treatment(P>0.05).The rates of spontaneous vaginal delivery and term delivery in the treatment group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the incidence of neonatal asphyxia and postpartum hemorrhage between the two groups(P>0.05).Conclusion The Low molecular weight heparin combined with Oral Rehydration Salts has efficacy on critical amniotic fluid oligohydramnios.