基于激光散斑成像的外科手术术中无标记实时血流监测方法

Intraoperative Label-free Blood Flow Measurement Based on Laser Speckle Imaging

外科手术术中需要对术野内组织血流灌注进行实时成像,传统方法通过注射吲哚菁绿荧光造影实现。提出了基于激光散斑成像的无标记实时血流监测方法,结合GPU并行计算和血流伪彩合成,实现手术术中血流的高分辨率监测。与传统荧光方法相比,该系统具有毫秒级的响应速度且不会增加手术难度,并且可以为术中评估提供重要支撑。通过对系统进行测试,整体成像速度达到65帧/s;在操作方面具有良好的人机界面。在临床外科手术术中监测应用中,具有很高的实用价值。

In the surgical operation,real-time imaging of the tissue perfusion and blood flow is important.Traditional method is achieved by injection and imaging of Indocyanine Green as fluorescence contrast.This paper proposes a labelfree intraoperative blood flow monitoring method based on laser speckle imaging,and combines GPU parallel computing and blood flow pseudo-color synthesis to achieve high-resolution blood flow monitoring during surgery.Compared with traditional fluorescence method,this system has a millisecond response speed without increasing the difficulty of surgery,and can provide important support for intraoperative evaluation.By testing the system,the imaging speed reaches 65 fps.It has a good user-computer interface.It shows valuable potentials in clinical surgical operations.