磁共振影像标志物对椎间盘退变及盘源性下腰痛诊断的研究进展

Progress of MR imaging markers in the diagnosis of intervertebral disc degeneration and discogenic low back pain

下腰痛在多数情况下为非特异性疼痛。在慢性下腰痛人群中,椎间盘源性下腰痛占39%~41%。椎间盘退变为椎间盘源性下腰痛的病理基础。常规MRI无法定量诊断椎间盘退变及椎间盘源性下腰痛,但随着定量磁共振技术的应用,无创检测退变椎间盘中的成分和结构成为可能。磁共振影像标志物是定量磁共振在对椎间盘组织进行扫描后得到的各种参数信息或图像,如T1ρ值、T2 mapping弛豫时间、ADC值、FA值、MTRasym值、Ksw值、△T1值、代谢物质的波谱信息等,通过对影像标志物的分析,可以定量测量椎间盘内特定物质的含量并反映椎间盘结构的变化,可为椎间盘退变的早期改变及椎间盘源性下腰痛提供准确而全面的信息。

Low back pain(LBP)is no specific pain in most cases,and 39%to 41%of which is discogenic LBP.Intervertebral disc degeneration(IVD)is basic pathologic change of discogenic LBP.Routine MRI can't quantitatively diagnose IVD and discogenic LBP,but with the application of quantitative MR technology,noninvasive ways to detect components and structure in intervertebral disc become possible.MR imaging markers are various parameter information or images obtained by quantitative MRI,such as T1ρvalue,T2 mapping relaxation time,ADC value,FA value,MTRasym value,Ksw value,△T1 value,spectral information of metabolic substances,etc.Through the analysis of these information,we can quantitatively measure the content of specific substances in the intervertebral disc and get information about the structure changes in the disc.MR imaging markers can provide accurate and comprehensive information for discogenic LBP and IVD in early stage.