喹诺酮类抗菌药物临床应用的研究近况

Recent Research on Clinical Application of Quinolones Antibacterials

对支原体、厌氧菌、革兰阳性菌和革兰阴性菌等病原体导致的各种感染性疾病,喹诺酮类抗菌药物为常见的治疗药物,该类药物的临床特点是口服吸收好、抗菌作用强、抗菌谱广等。并且此类药物仍在不断扩大使用适应证,但随之不良反应的发生率也呈上升趋势。喹诺酮类抗菌药物以变态反应、心血管系统反应、中枢神经系统反应、胃肠道反应等为主要的不良反应。正确合理使用喹诺酮类抗菌药物避免了不良反应的发生,促进了临床使用。综述喹诺酮类抗菌药物临床研究的文献,并对其的临床研究近况做了分析。

For various infectious diseases caused by Mycoplasma,Anaerobic bacteria,Gram-positive bacteria,Gram-negative bacteria,etc.,quinolones antibacterials are common therapeutic drugs,which are characterized by good oral absorption,strong antibacterial effect and wide antibacterial spectrum.In addition,the indications of such drugs are still expanding,but the incidence of adverse reactions is also on the rise.The main adverse reactions of quinolones include allergic reaction,cardiovascular system reaction,central nervous system reaction and gastrointestinal reaction.The correct and rational use of quinolones prevents the occurrence of adverse reactions and promotes the clinical medication.The literature of clinical research on quinolones was reviewed and the clinical research status was analyzed.