急性期哮喘患者血清25(OH)D3水平与疾病严重程度及其相关指标的相关性

Correlation of Serum 25(OH)D3 Level with Acute Asthma Severity and Related Indicators

【目的】探讨急性期哮喘患者血清25-羟维生素D3[25(OH)D3]水平与疾病严重程度及其相关指标的相关性.【方法】选取2016年3月至2018年2月在本院呼吸内科诊治的72例急性期哮喘患者(观察组),按照哮喘严重程度分为轻、中、重3组,其中轻度组为18例,中度组为28例,重度组为26例.同时选取在本院体检中心53例健康志愿者作为对照组.检测所有入选人员血清25(OH)D3、高敏C反应蛋白(Hs-CRP)、钙、无机磷、碱性磷酸酶水平.采用肺功能检测仪测定哮喘患者一秒钟用力呼气量占预计值的百分比(FEV1%),分析哮喘患者血清25(OH)D3水平与疾病严重程度及与其相关指标的相关性.【结果】观察组25(OH)D3水平明显低于对照组,Hs-CRP水平显著高于对照组,其差异均有统计学意义(P<0.05).FEV1%和25(OH)D3水平轻度组、中度组、重度组依次降低;Hs-CRP水平轻度组、中度组、重度组依次升高,三组比较差异均有统计学意义(P<0.05).Pearson相关性分析:哮喘患者25(OH)D3与FEV1%呈正相关(r=0.755,P<0.05),与Hs-CRP呈负相关(r=-0.804,P<0.05).【结论】急性哮喘患者病情越严重,25(OH)D3水平越低、肺功能越差越易诱导炎症反应;同时25(OH)D3与肺功能指标FEV1%呈正相关,与血清hs-CRP呈负相关.

【Objective】To explore the relationship of serum 25(OH)D3 level with disease severity and related indexes in patients acute asthma.【Methods】A total of 72 patients with acute asthma diagnosed and treated in the Department of Respiratory Medicine in our hospital from March 2016 to February 2018 were enrolled as the observation group.According to the severity of asthma,patients in the observation group were further divided into three sub-groups,including 18 cases in the mild group,28 cases in the moderate group,and 26 cases in the severe group.At the same time,53 healthy volunteers in our physical examination center were selected as the control group.Serum 25-hydroxyvitamin D3(25(OH)D3)levels,high-sensitivity C-reactive protein(Hs-CRP)levels,serum calcium,serum in organic phosphorus,and serum alkaline phosphatase were measured.Pulmonary function tester was used to measure the forced expiratory volume in one second of asthma patients as a percentage of the predicted value(FEV1%).The correlation of serum 25(OH)D3 level with disease severity and related indexes in acute asthma patients was explored.【Results】The 25(OH)D3 level in the observation group was significantly lower than that in the control group(P V0.05),and the Hs-CRP level in the observation group was significantly higher than that in the control group(P<0.05).The levels of both FEV1%and 25(OH)D3 in the mild group,moderate group and severe group decreased in turn(P V0.05),while the Hs-CRP levels in the mild group,moderate group and severe group increased in sequence(P<0.05).The differences were statistically significant(P<0.05).Pearson correlation analysis showed that 25(OH)D3 in the observation group was positively correlated with FEV1%(r=0.755,P<0.05)and negatively correlated with Hs-CRP(r=-0.804,P<0.05).【Conclusion】The serum 25(OH)D3 level in patients with acute asthma is inversely proportional to the severity of the disease,namely the more severe the condition,the lower the 25(OH)D3 level.At the same time,it is positively correlated with FEV1%value and negatively correlated with serum hs-CRP.The lower the serum 25(OH)D3 level,the worse the lung function in patients with acute asthma and the more likely to induce inflammation.