曲美他嗪治疗高血压性心脏病的临床效果及对氧化应激指标水平的影响

Clinical Effect of Trimetazidine in the Treatment of Hypertensive Heart Disease and its Effect on the Level of Oxidative Stress Index

【目的】探讨曲美他嗪治疗高血压性心脏病(简称高心病)患者的临床效果及对氧化应激指标水平的影响.【方法】选取本院收治的88例高心病患者,根据治疗方法不同将其分为对照组(常规降压、降脂、抗血小板或者抗凝治疗,n=48)和观察组(在对照组的基础上联合曲美他嗪,n=40).比较两组患者治疗的临床效果及其心功能[左室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVDD)、左房内径(LAD)]、氧化应激[超氧化酶歧化酶(SOD)、丙二醛(MDA)、活性氧类(ROS)]水平的变化.【结果】观察组患者总有效率为90.00%(36/40),高于对照组的68.75%(33/48),差异有统计学意义(χ^2=7.940,P=0.005<0.05).治疗后,两组患者LVEF水平高于治疗前,LVESD、LAD、LVDD水平低于治疗前,且两组间比较,差异均有统计学意义(均P<0.05).治疗后,两组血清SOD水平高于治疗前,MDA、ROS水平低于治疗前,且两组间比较,差异均有统计学意义(均P<0.05).【结论】曲美他嗪可有效辅助治疗高心病,较好地改善患者的心功能,并能够减轻患者机体氧化应激反应,值得临床借鉴.

【Objective】To investigate the clinical effect of trimetazidine on hypertensive heart disease and its effect on oxidative stress index level.【Methods】Eighty-eight patients with hypercardiac disease were selected and divided into control group(routine antihypertensive,lipid-lowering,antiplatelet or anticoagulant therapy,n=48)and observation group(combined with trimetazidine on the basis of control group,n=40).The clinical effects and the changes of cardiac function(LVEF,LVESD,LVDD,LAD),oxidative stress(SOD,MDA,ROS)were compared between the two groups.【Results】The total effective rate of observation group was 90.00%(36/40),which was higher than that of control group(68.75%)(33/48).The difference was statistically significant(χ^2=7.940,P=0.005<0.05).After treatment,the LVEF level of the two groups was higher than that before treatment,and the levels of LVESD,lad and LVDD were lower than those before treatment,and the differences between the two groups were statistically significant(mean P<0.05).After treatment,the serum SOD level of the two groups was higher than that before treatment,the MDA and ROS levels were lower than that before treatment,and the difference between the two groups was statistically significant(mean P<0.05).【Conclusion】Trimetazidine can effectively assist in the treatment of high heart disease,improve the heart function of patients,and reduce the oxidative stress response of patients,which is worthy of clinical reference.