不同针灸疗法干预关节炎炎症反应的机制研究进展

Advances in research on mechanism of different acupuncture treatments intervention on arthritis inflammatory response

关节炎是一系列以关节及关节周围组织,因炎症、感染、创伤、退化或其他因素引起的炎性疾病。近年来关节炎的患病率显著增加,临床上代表性关节炎有类风湿关节炎、脊柱关节炎(以强直性脊柱炎为典型)、痛风、骨关节炎等。近年来的研究逐渐重视这些疾病中炎性细胞因子的研究,包括白介素(IL)家族系列中多种炎性因子及肿瘤坏死因子-α(TNF-α)。最新研究发现针灸在此类疾病的治疗中,可能参与相关炎性因子的致病途径,并通过调控此类细胞因子水平,从而改善炎症反应,为临床运用针灸治疗关节炎提供了理论及实验依据。

Arthritis is a series of inflammatory diseases caused by inflammation,infection,trauma,degeneration or other factors in joints and tissues around joints.In recent years,the prevalence rate of arthritis has increased significantly.Clinically,representative arthritis include rheumatoid arthritis,spinal arthritis(typified by ankylosing spondylitis),gout,osteoarthritis,etc.In recent years,research has gradually attached importance to the study of inflammatory cytokines in these diseases,including a variety of inflammatory factors in the interleukin family(IL)and tumor necrosis factor alpha(TNF-α).Recent studies have found that acupuncture and moxibustion may participate in the pathogenic pathway of relevant inflammatory factors in the treatment of such diseases,and through regulating the level of such cytokines,thus improving inflammatory response,providing theoretical and experimental basis for clinical application of acupuncture and moxibustion in the treatment of arthritis.