阴道微生态与不孕症及其IVF-ET术后妊娠结局的相关性探讨

Correlation between vaginal micro-ecology and infertility as well as pregnancy outcome of IVF-ET

不孕症的病因复杂而多样,给临床诊疗带来困难。随着阴道微生态的研究进展和微生物测序等技术的更新,越来越多的证据显示阴道微生态菌群与宿主之间的相互作用可能对女性的生育力产生影响,阴道微生态失调与输卵管、子宫内膜等因素引起的不孕症的发生发展存在关联。另外,体外受精-胚胎移植(IVF-ET)技术已成为治疗不孕症的主要手段,在IVF-ET治疗过程中阴道微生态会因控制性促排卵、手术操作等的影响而发生改变从而对助孕结局产生影响,但其相关性和作用机制尚不明确。本文对上述问题进行综述,以期为不孕症患者的诊疗提供新的思路。

The causes of infertility are complex and varied,which causes difficulties in clinical diagnosis and treatment.With the research progress of vaginal microecology and the renewal of microbial sequencing technology,more and more evidences suggest that the interaction between vaginal microbiota and host may have the effects on female fertility,and vaginal microbiota dysbiosis may take part in the occurrence and development of infertility caused by fallopian tube and endometrium factors.In addition,IVF-ET has become the main technique for treatment of infertility.The vaginal micro-ecology may be changed due to the influence of controlled super-ovulation stimulation or surgical operation during IVF-ET cycles,which will affect the outcome of assisted pregnancy,but the correlation and mechanism are not clear.This paper reviews the above-mentioned problems in order to provide new ideas for the diagnosis and treatment of infertility patients.