他唑巴坦合成中环合反应中间体的异构体分离与二维核磁解析

Isolation and 2D-NMR analysis of intermediate isomer in the synthesis of tazobactam

他唑巴坦是日本大鹏药业公司开发的一种重要的β-内酰胺酶抑制剂。利用柱层析对其合成中环合反应的六元环异构体杂质进行分离,并用核磁氢谱1H-NMR、碳谱13C-NMR、二维核磁相关谱1H-1HCOSY、HSQC、HMBC以及DEPT135对分离的六元环异构体杂质进行了结构归属解析。

Tazobactam is an importantβ-lactamase inhibitor developed by Japan Taiho pharmaceutical company.The impurity of six-membered ring isomer in the cyclization reaction of tazobactam synthesis was isolated by column chromatography and analyzed by 1H-NMR,13C-NMR,1H-1HCOSY,HSQC,HMBC and DEPT135.