联芳基高碘化合物的合成反应研究

Systematic Study on the Synthesis of Cyclic Diaryliodonium Salts

苯胺类化合物和芳硼酸在交叉偶联反应条件下可以制得2-芳基苯胺类化合物,利用其氨基分步进行碘代、氧化-环化反应从而制得对应的联芳基高碘化合物;分别对交叉偶联反应(A)过程的溶剂、无机碱种类、温度和碘代反应(B)过程Na NO2溶液浓度,及氧化-环化反应(C)过程的溶剂等反应条件进行了优化,分别得到了最佳合成反应条件,并利用两种不同的苯胺类化合物进行了底物拓展研究.

Aniline compounds and arylboronic acids can be used to prepare 2-arylaniline compounds under cross-coupling reaction conditions.The amino groups are then used to perform the iodine,oxidation-cyclization reaction in steps to obtain corresponding biaryl high iodine compounds.The reaction conditions such as solvent,inorganic base type,temperature of cross-coupling reaction(A),concentration of NaNO2 solution during iodine reaction(B)and solvent of oxidation-cyclization reaction(C)were optimized.In addition,substrate expansion studies were carried out.