2型糖尿病合并高同型半胱氨酸血症与动脉硬化性脑梗死的关系研究进展

Research Progress of the Relationship between Type 2 Diabetes Mellitus Combined with Hyper Homocysteineme and Atherosclerotic Cerebral Infarction

脑梗死是2型糖尿病(T2DM)的大血管病变之一,占糖尿病性脑血管病的89%,已成为T2DM患者致死、致残的主要原因。高同型半胱氨酸血症(Hhcy)指血清中同型半胱氨酸(Hcy)水平增高达10μmol/L以上,Hhcy与糖尿病、动脉粥样硬化(AS)、脑卒中等疾病密切相关。T2DM、Hhcy同为脑梗死的危险因素,本文旨在简述Hcy的代谢、T2DM与Hhcy的关系、T2DM合并Hhcy与动脉硬化性脑梗死的关系及相关机制。

Cerebral infarction is one of the major vascular diseases of type 2 diabetes mellitus(T2DM),accounting for 89%of diabetic cerebrovascular disease,and it has become the main cause of death and disability in T2DM patients.Hyper homocysteinemia(Hhcy)refers to the increase in serum homocysteine(Hcy)up to 10μmol/L or more.Stroke diseases are closely related.T2DM and Hhcy are both risk factors for cerebral infarction,so this article aims to briefly describe the metabolism of homocysteine(Hcy),the relationship between T2DM and Hcy,the relationship between T2DM combined with Hhcy and atherosclerotic cerebral infarction.