硬化性肺泡细胞瘤22例临床病理学回顾性分析

Retrospective analysis on clinical pathology of 22 cases of pulmonary sclerosing pneumocytoma

目的探讨硬化性肺泡细胞瘤(PSP)的临床病理学特点及鉴别诊断,提高对该病的认识及诊断水平。方法回顾分析22例PSP患者的组织学形态及免疫组化表型并复习相关文献。结果镜下观:肿瘤组织主要由4种组织形态(实性区、乳头状区、出血区和硬化区)和2种肿瘤细胞(立方样细胞和间质细胞)构成。免疫组织化学表型:两种细胞都表达EMA和TTF-1;立方样细胞表达CK-pan;间质细胞表达TTF-1和Vimentin。结论结合影像学检查、大体观、形态学特征及免疫组化结果是目前确诊PSP的有效方法。

Objective To investigate the clinicopathological features and differential diagnosis of 22 cases of pulmonary sclerosing pneumocytoma(PSP),and to improve the understanding and diagnosis of the disease.Methods Histological morphology and immunohistochemical phenotype of 22 PSP patients were analyzed retrospectively,and related literature were reviewed.Results Microscope showed that tumor tissue was mainly composed of 4 kinds of tissue morphology(solid area,papillary area,bleeding area and sclerotic area)and 2 kinds of tumor cells(cubic like cells and interstitial cells).Immunohistochemical phenotype showed that both cells expressed EMA and TTF-1,cubic cells expressed CK-pan,and interstitial cells expressed TTF-1 and Vimentin.Conclusion It is an effective method to diagnose PSP by combining imaging examination,general view,morphological characteristics and immunohistochemical results.