摘要
炎症性肠病(IBD)是一种病因与发病机制不明的、慢性非特异性肠道炎症性疾病,常伴随有肠外表现,可涉及包括肝胆胰在内的多个器官累及,对IBD的预后转归有重要的影响。肝胆胰器官并发症主要包括原发性硬化性胆管炎、原发性胆汁性胆管炎、自身免疫性肝炎、IgG4相关性硬化性胆管炎、急性胰腺炎、慢性胰腺炎、自身免疫性胰腺炎、非特异性胰酶升高等。IBD相关肝胆胰并发症的发生是在具有遗传易感性的个体中,环境因素和免疫因素等共同作用下所致,综述了其发病机制的相关研究进展。
Inflammatory bowel disease( IBD) is a non-specific chronic intestinal inflammatory disease with unknown etiology and pathogenesis and is often accompanied by extraintestinal manifestations involving multiple organs including the liver,the gallbladder,and the pancreas,with an important impact on the prognosis of IBD. Hepatobiliary and pancreatic complications mainly include primary sclerosing cholangitis,primary biliary cholangitis,autoimmune hepatitis,IgG4-associated sclerosing cholangitis,acute pancreatitis,chronic pancreatitis,autoimmune pancreatitis,and nonspecific increase in pancreatic enzyme. IBD-related hepatobiliary and pancreatic complications are caused by the combination of environmental and immune-mediated factors in individuals with genetic susceptibility,and this article summarizes the current research advances in the pathogenesis of such hepatobiliary inflammatory bowel disease;liver diseases;biliary tract diseases;pancreatic diseases;and pancreatic complications.
作者
高翔
刘占举
GAO Xiang;LIU Zhanju(Department of Gastroenterology,Shanghai Tenth People’s Hospital,Shanghai 200072,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第7期1467-1473,共7页
Journal of Clinical Hepatology
基金
国家自然科学基金项目(81630017,91942312)。
关键词
炎症性肠病
肝疾病
胆道疾病
胰腺疾病
inflammatory bowel disease
liver diseases
biliary tract disease
pacreatic diseases