基于肠-肝轴理论探讨非酒精性脂肪性肝病和肠道菌群的关系

Association between nonalcoholic fatty liver disease and gut microbiota based on the theory of gut-liver axis

非酒精性脂肪性肝病(NAFLD)目前已成为最主要的慢性肝病,被认为是代谢综合征的肝脏表现,后期可能向肝纤维化及肝硬化,甚至是肝癌发展。肠道菌群作为人体重要的共生物,影响人体的代谢功能,可能和NAFLD的发病密切相关。肠-肝轴理论为"肠道菌群失调可引起肝脏改变"提供了理论基础。探讨了肠道菌群和NAFLD发病的关系,为后期研究肠道菌群靶向治疗NAFLD奠定理论基础。

Nonalcoholic fatty liver disease(NAFLD)has become the most important chronic liver disease and is recognized as the hepatic manifestation of metabolic syndrome,which may progress to liver fibrosis,liver cirrhosis,and even hepatocellular carcinoma in the advanced stage.Gut microbiota,as important symbiotic organisms in the human body,affects metabolic function and may be closely associated with NAFLD,and the theory of gut-liver axis provides a theoretical basis for understanding that intestinal dysbacteriosis may cause liver pathological changes.This article explores the association between NAFLD and gut microbiota,so as to lay a theoretical foundation for the future research on the therapy for NAFLD targeting gut microbiota.