基于数据挖掘吴生元教授辨治痛风用药规律研究

Research on Professor Wu Shengyuan’s Differentiation of Gout Medication Based on Data Mining

目的通过检索吴生元教授门诊记录的痛风医案,分析吴教授治疗痛风用药规律,以期为吴生元教授治疗痛风的临床经验传承与创新,为临床治疗痛风提供借鉴。方法应用中医传承辅助平台系统(V2.5)对方剂及医案原始资料进行统计分析及归纳,总结其用药规律。结果通过对105首方剂分析,涉及中药79味,使用频次≥10次的药物共34味,经典组合模式42条,高频药物关联程度大致6组,常用药对51条,并演化得到3首治疗痛风的新处方,药组多以祛风除湿通络药物为主。结论吴生元教授治疗痛风多以清热养阴、散寒除湿、温通经络、健脾渗湿等立法,处方常寒热共用、通补结合,注重顾护脾胃、扶正与祛邪并举,形成了独具特色的诊治经验,值得大家借鉴。

Objective By retrieving the gout medical records of Professor Wu Shengyuan’s outpatient clinic,the analysis of Professor Wu’s medications for gout is analyzed,with a view to inheriting and innovating Professor Wu Shengyuan’s clinical experience in treating gout,and providing a reference for clinical treatment of gout.Methods The traditional Chinese medicine inheritance auxiliary platform system(V2.5)was used for statistical analysis and induction of the other agents and medical records to summarize their medication laws.Results According to the analysis of 105 prescriptions,79 flavors of Chinese medicine are involved,34 flavors of drugs are used frequently≥10 times,42 classic combination modes,and the high-frequency drug association degree is roughly 6 groups,51 commonly used medicine pairs,and 3 treatments have evolved.For the new prescription of gout,the drug group is mainly based on Qufeng Dehumidification and Tongluo drugs.Conclusion Professor Wu Shengyuan mostly treats gout with legislation such as clearing heat and nourishing yin,dispersing cold and dehumidifying,warming the meridians,and strengthening the spleen and soaking wet,and prescribes common cold and heat,combined with tonic,and focuses on spleen and stomach care,righteousness,and elimination of evil,forming a unique feature.The experience of diagnosis and treatment is worth learning from.