探讨血府逐瘀汤对冠心病患者血脂、血清炎性因子及内皮功能的影响

To Study the Effect of Xuefu Zhuyu Decoction on Blood Lipid,Serum Inflammatory Factors and Endothelial Function in Patients with Coronary Heart Disease

目的探讨血府逐瘀汤对冠心病患者血脂、血清炎性因子及内皮功能等相关指标水平的影响。方法研究对象为2018年1月至2019年1月期间于本院心血管内科住院治疗的冠心病患者110例,随机分为实验组和对照组各55例。对照组患者予常规治疗,实验组患者在常规治疗的基础上予血府逐瘀汤治疗,共治疗24周。24周后对比两组患者血脂、血清炎性因子及内皮功能等指标水平。结果 24周后,两组患者血脂、血清炎性因子及内皮功能等指标水平均较治疗前改善,实验组患者改善程度显著优于对照组,差异有统计学意义(P<0.05)。结论血府逐瘀汤可显著降低冠心病患者的血脂水平,抑制炎性反应,保护血管内皮功能,从而减少动脉粥样硬化引起的心脑血管意外,提高冠心病治疗效果,值得临床广泛推广应用。

Objective To study the effect of xuefu zhuyu decoction on blood lipid,serum inflammatory factors and endothelial function in patients with coronary heart disease.Methods 110 patients with coronary heart disease who were hospitalized in the department of cardiovascular medicine of our hospital from January 2018 to January 2019 were selected as subjects for this study,who were randomly divided into the experimental group and the control group.The control group received conventional treatment ang the experimental group was treated with xuefu zhuyu decoction on the basis of conventional treatment.Patients in both groups were treated for 24 weeks.serum lipids,inflammatory cytokines and endothelial functions of the two groups were compared after 24 weeks.Results after 24 weeks,the levels of serum lipid,inflammatory cytokines and endothelial function in the two groups were all improved compared with those before treatment,but the improvement degree of the experimental group was significantly better than that of the control group,the difference was significant and statistically significant(P<0.05).Conclusions Xuefu zhuyu decoction can significantly reduce the level of blood lipid in patients with coronary heart disease,inhibit inflammatory reaction,protect vascular endothelial function,so that it can reduce the cardiovascular and cerebrovascular accidents caused by atherosclerosis,and improve the treatment effect of coronary heart disease.It is worthy of wide clinical application.