米力农联合去乙酰毛花苷注射液治疗慢性心力衰竭患者的疗效

Efficacy of Milrinone Combined with Deacetyllanoside Injection in the Treatment of Patients with Chronic Heart Failure

目的:探讨米力农联合去乙酰毛花苷注射液治疗慢性心力衰竭患者的临床疗效。方法:选取我院慢性心力衰竭者104例,随机单盲法分为研究组(n=52)、常规组(n=52)。常规组采用去乙酰毛花苷注射液治疗,研究组于常规组基础上采用米力农治疗,统计比较两组治疗5d后临床疗效、治疗前、治疗5d后心功能指标[左心室舒张末内径(LVEDD)、左心房内径(LA)、左心室射血分数(LVEF)]及6min步行距离、血清N末端B型脑钠肽前体(NT-proBNP)水平、不良反应发生率。结果:研究组治疗总有效率92.31%显著高于常规组75.00%(P<0.05);治疗5d后研究组LVEDD、LA低于常规组,LVEF高于常规组(P<0.05);治疗5d后研究组6min步行距离长于常规组,血清NT-proBNP水平低于常规组(P<0.05);研究组不良反应发生率9.62%与常规组5.77%比较无显著差异(P>0.05)。结论:米力农联合去乙酰毛花苷注射液治疗慢性心力衰竭患者疗效显著,可改善其心功能,提高患者运动耐量,且安全性高。

Objective:To investigate the clinical efficacy of milrinone combined with deacetyllanosine injection in the treatment of patients with chronic heart failure.Methods:104 patients with chronic heart failure in our hospital were randomly divided into Study Group(n=52)and routine group(n=52).The routine group was treated with injection of deacetyllanoside.The study group was treated with milrinone on the basis of the routine group,the clinical effect,the level of NT-proBNP and the incidence of adverse reactions were compared between the two groups after 5d treatment,before treatment and after 5d treatment.The parameters of left ventricular function were left ventricular end diastolic diameter LVEDD,left atrial inner diameter,left ventricular ejection fraction and 6 minute walking distance.Results:The total effective rate of the study group was 92.31%significantly higher than that of the routine group(75.00%,P<0.05),the LVEDD and La of the study group was lower than that of the routine group(P<0.05),the LVEF of the study group was higher than that of the routine group(P<0.05),and the sixminute walking distance of the study group was longer than that of the routine group(P<0.05),the level of NT-proBNP in serum was lower than that in routine group(P<0.05),and the incidence of adverse reaction in study group was 9.62%compared with 5.77%in routine group(P>0.05).Conclusion:Milrinone combined with deacetyllanoside injection is effective in the treatment of patients with chronic heart failure.It can improve the cardiac function and exercise tolerance.