益肾活血协定方对CKD4~5期肾性骨病患者肾功能及钙磷代谢的影响

Effects of Yishen Huoxue Prescription on Renal Function and Calcium and Phosphorus Metabolism in Patients with CKD4-5 Renal Osteodystrophy

目的:分析益肾活血协定方对慢性肾功能不全CKD4~5期肾性骨病患者肾功能及钙磷(Ca2+、P3-)代谢的影响。方法:选取我院62例CK D4~5期肾性骨病患者(2017年7月至2019年6月),随机化分组。对照组31例实施常规西医治疗,研究组31例在对照组基础上予以益肾活血协定方治疗。对比2组治疗效果、治疗前后肾功能[血肌酐(Scr)、尿素氮(BUN)]、Ca2+、P3-水平。结果:研究组总有效率(87.10%)高于对照组(64.52%)(P<0.05);研究组治疗3个疗程后Scr、BUN、P3-水平低于对照组,Ca2+水平高于对照组(P<0.05)。结论:益肾活血协定方治疗CKD4~5期肾性骨病,疗效确切,能改善肾功能,调节钙磷代谢。

Objective:To analyze the effects of Yishen Huoxue prescription on renal function and calcium and phosphorus(Ca2+,P3-)metabolism in patients with renal osteopathy(CKD4-5).Methods:62 patients with CKD4-5 renal osteodystrophy(from July 2017 to June 2019)were randomly divided into two groups.The Control Group(31 cases)was treated with conventional western medicine,and the study group(31 cases)was treated with the prescription of tonifying kidney and promoting blood circulation.The therapeutic effects,serum creatinine(Scr),blood urea nitrogen(BUN),Ca2+and P3-levels were compared between the two groups.Results:The total effective rate(87.10%)in the study group was higher than that in the control group(64.52%,P<0.05),the levels of Scr,BUN and P3-in the study group were lower than that in the control group,and the level of Ca2+in the study group was higher than that in the control group(P<0.05).Conclu sion:Yishen Huoxue prescription is effective in treating CKD4-5 stage renal osteodystrophy.It can improve renal function and regulate calcium and phosphorus metabolism.