两种不同降压药治疗重度子痫前期的临床疗效对比

Comparison of Clinical Effects of Two Different Antihypertensive Drugs on Severe Preeclampsia

目的:对比两种不同降压药治疗重度子痫前期的临床疗效。方法:2019年1月至2019年12月,将本院收治的120例重度子痫前期患者作为本次研究对象,纳入患者均依循双色球分组法进行分组,其中采用硝苯地平治疗的60例患者为对照组,采用拉洛贝尔治疗的60例患者为观察组,在两组完成疗程、分娩后,评估两组患者的临床治疗效果。结果:观察组60例的临床治疗有效率明显大于对照组,差异具有统计学意义(P<0.05)。两组治疗前的血压水平对比,差异无统计学意义(P>0.05);两组治疗后的血压水平明显下降,观察组治疗后的血压水平明显低于对照组,差异具有统计学意义(P<0.05)。观察组60例的围产不良结局发生率(低体质量儿、新生儿窒息、新生儿呼吸窘迫、产后出血、产褥感染)小于对照组,差异具有统计学意义(P<0.05)。结论:拉洛贝尔、硝苯地平用于治疗重度子痫前期,均有一定效果。但拉洛贝尔的整体治疗效果更为理想,患者的血压水平改善更为显著,患者的围产不良结局发生率更低,预后情况更好,更具有临床应用价值,可作为临产用药的首选方案。

Objective:To compare the clinical effects of two different antihypertensive drugs on severe preeclampsia.Meth ods:F rom January 2019 to December 2019,120 patients with severe preeclampsia in our hospital were divided into two groups,60 patients treated with nifedipine were the control group and 60 patients treated with Lalobel were the observation group.Re sults:The effective rate of 60 cases in the observation group was significantly higher than that in the control group(P<0.05).There was no significant difference in blood pressure level between the two groups before treatment(P>0.05);the blood pressure level of the two groups decreased significantly after treatment,and the blood pressure level of the observation group was significantly lower than that of the control group after treatment,with a significant difference(P>0.05).The incidence of perinatal adverse outcomes(low body mass infants,neonatal asphyxia,neonatal respiratory distress,postpartum hemorrhage,puerperal infection)in 60 cases in the observation group was smaller than that in the control group(P<0.05).Conclusion:Lalobel and nifedipine are effective in the treatment of severe preeclampsia.But the overall effect of Lalobel's treatment is more ideal,the patient's blood pressure water.The improvement of ping is more significant,the incidence of perinatal adverse outcome is obviously lower,the prognosis is obviously better,and it has more clinical application value,so it can be used as the first choice of drug use in forest farm.