吗替麦考酚酯联合注射用甲泼尼龙琥珀酸钠冲击治疗紫癜性肾炎患者的疗效观察

Efficacy of Mycophenolate Mofetil Combined with Methylprednisolone Sodium Succinate in the Treatment of Purpura Nephritis

目的:探讨吗替麦考酚酯联合注射用甲泼尼龙琥珀酸钠冲击治疗紫癜性肾炎的临床效果。方法:选取我院2016年3月至2018年12月75例紫癜性肾炎患者,按治疗方案分联合组(n=38)、常规组(n=37)。常规组予以注射用甲泼尼龙琥珀酸钠冲击治疗,联合组予以吗替麦考酚酯联合注射用甲泼尼龙琥珀酸钠冲击治疗。对比两组疗效、不良反应、治疗前及治疗2个疗程后肾功能[血肌酐(Scr)、尿素氮(BUN)水平、24h尿蛋白定量(24hPRO)]。结果:联合组总有效率89.47%(34/38)较常规组67.57%(25/37)高(P<0.05);治疗2个疗程后联合组血清Scr、BUN水平、24hPRO低于常规组(P<0.05);联合组不良反应发生率2.63%(1/38)与常规组0.00%(0/37)对比,无显著差异(P>0.05)。结论:吗替麦考酚酯、注射用甲泼尼龙琥珀酸钠冲击联合治疗紫癜性肾炎疗效显著,能有效改善肾功能,且不良反应少,安全性高。

Objective:To investigate the clinical effect of mycophenolate mofetil combined with methylprednisolone sodium succinate for injection in the treatment of purpura nephritis.Methods:75 patients with Henoch Schonlein purpura nephritis in our hospital from March 2016 to December 2018 were divided into combined group(n=38)and conventional group(n=37)according to the treatment plan.The routine group was treated with methylprednisolone and sodium succinate,while the combined group was treated with mycophenolate and methylprednisolone and sodium succinate.The renal function(SCR,BUN,24hPRO)before and after treatment were compared.Results:The total effective rate of the combined group was 89.47%(34/38)higher than that of the conventional group(67.57%(25/37)(P<0.05));the levels of serum SCR,bun and 24hPRO in the combined group were lower than those in the conventional group(P<0.05);the incidence of adverse reactions in the combined group was 2.63%(1/38)and 0.00%(0/37)respectively,with no significant difference(P>0.05).Conclusion:The combined therapy of mycophenolate mofetil and methylprednisolone sodium succinate for injection is effective in the treatment of Henoch Schonlein purpura nephritis.