直接灸四花穴对肺癌化疗患者血清CSF、TNF、IL-2的影响

Effect of Direct Moxibustion to Sihua Points on Serum Levels of CSF,TNF and IL-2 in Patients with Lung Cancer undergoing Chemotherapy

目的:探究直接灸四花穴对肺癌化疗患者血清CSF、TNF、IL-2的影响。方法:纳入60例肺癌化疗患者为研究对象,均为我院2016年1月—2018年1月收治的患者,将纳入患者按随机数字表法分为对照组与观察组,各30例。对照组采用长春瑞滨+顺铂化疗方案,并给予常规预防化疗毒副反应等药物,观察组在对照组治疗的基础上给予直接灸四花穴治疗,两组均连续治疗8 d。统计两组治疗后临床疗效;比较两组患者治疗前后血清CSF、IL-2、TNF的差异;比较两组患者生存质量、体力状况及毒副反应的差异。结果:观察组患者总有效率为86.67%(26/30),高于对照组的63.33%(19/30)(P<0.05);治疗后观察组患者血清CSF和IL-2水平均较治疗前升高,且高于对照组(P<0.05);观察组血清TNF水平较治疗前下降,且低于对照组(P<0.05);观察组患者治疗后FACT-L评分较治疗前显著升高(P<0.05),对照组患者治疗后Karnofsky评分比治疗前显著下降(P<0.05),观察组FACT-L评分和Karnofsky评分均显著高于对照组(P<0.05);观察组患者失眠、白细胞减少以及恶心呕吐的发生率显著低于对照组(P<0.05)。结论:直接灸四花穴可提高肺癌化疗患者的临床疗效,提高血清CSF、IL-2水平,降低血清TNF水平,减轻患者毒副反应,改善患者生存质量和体力状况,值得临床推广应用。

Objective:To explore the effect of direct moxibustion to Sihua points(Geshu points and Danshu points)on serum levels of CSF,TNF and IL-2 in patients with lung cancer undergoing chemotherapy.Methods:60 patients with lung cancer undergoing chemotherapy were included in this study.They were randomly divided into the control group and the observation group,with 30 cases in each group.The control group was treated with chemotherapy of Vinorelbine and Cisplatin,and the routine medication to prevent side effects of chemotherapy was applied;on which basis,the observation group was also treated with direct moxibustion to Sihua points.Both groups were treated continuously for 8 days.The clinical efficacy was compared in the two groups.The serum levels of CSF,IL-2 and TNF before and after the treatment were observed and compared in the two groups.The quality of life,physical condition and adverse reactions were also compared between the two groups.Results:The total effective rate of the observation group was 86.67%(26/30),which was significantly higher than 63.33%(19/30)of the control group(P<0.05).After the treatment,the serum levels of CSF and IL-2 were higher and the serum level of TNF was lower in the observation group compared to those before the treatment(P<0.05);of which the changes in the observation group were more significant than those in the control group(P<0.05).The FACT-L score was higher after the treatment than that before the treatment in the observation group(P<0.05).The Karnofsky score was significantly lower after the treatment than that before the treatment in the control group(P<0.05).The FACT-L score and the Karnofsky score were both significantly higher in the observation group than those in the control group(P<0.05).The incidence of nausea,leucopenia and vomiting was significantly less in the observation group than that in the control group(P<0.05).Conclusion:Direct moxibustion to Sihua acupoints can improve the clinical curative effect of lung cancer in the patients undergoing chemotherapy,it can increase the serum levels of CSF and IL-2,reduce the serum level of TNF,alleviate the toxic and side effects,improve the quality of life and physical condition of the patients.The therapy is worthy of clinical application.