西黄丸联合新辅助化疗对晚期宫颈癌患者预后及Th1/Th2细胞因子的影响

Effects of Xihuang Pill Combined with Neoadjuvant Chemotherapy on the Prognosis and Th1/Th2 Cytokines in Patients with Advanced Cervical Cancer

目的:探讨西黄丸联合新辅助化疗对晚期宫颈癌患者预后及辅助性T细胞1(Th1)/辅助性T细胞2(Th2)细胞因子的影响。方法:采用类实验性非同期对照研究法将2015年2月~2018年3月我院收治的82例晚期宫颈癌患者分为观察组与对照组,对照组采用新辅助化疗,观察组在对照组基础上给予西黄丸。对比两组患者临床疗效、Th1/Th2细胞因子、肿瘤标志物水平、生存率、复发率及不良反应。结果:观察组总有效率(90.24%)高于对照组(73.17%),存在统计学差异(P<0.05)。治疗后观察组γ-干扰素(IFN-γ)、白细胞介素-2(IL-2)水平高于对照组,白细胞介素-4(IL-4)、白细胞介素-6(IL-6)水平低于对照组(P<0.05)。治疗后两组患者血清癌胚抗原(CEA)与糖类抗原125(CA125)水平较治疗前下降,且观察组低于对照组(P<0.05)。观察组6个月、12个月复发率低于对照组,生存率高于对照组,但两组比较无统计学差异(P>0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论:西黄丸联合新辅助化疗可改善晚期宫颈癌患者预后,提高疗效,调节细胞免疫功能,减少不良反应。

Objective:To explore the effects of Xihuang pill combined with neoadjuvant chemotherapy on the prognosis and Th1/Th2 cytokines in patients with advanced cervical cancer.Methods:82 patients with advanced cervical cancer admitted to our hospital from February 2015 to March 2018 were divided into observation group and control group according to the experimental non-concurrent control study method.The control group received new adjuvant chemotherapy,and the observation group was given additional Xihuang Pill on that basis.The clinical efficacy,Th1/Th2 cytokines,tumor markers,survival rate,recurrence rate and adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 90.24%,higher than the control group(73.17%,P<0.05).After treatment,the observation group shows higher level of expression ofγ-interferon(IFN-γ)and interleukin-2(IL-2),and lower expression of interleukin-4(IL-4)and interleukin-6(IL-6)while comparing with the control group(P<0.05).After treatment,the levels of serum carcinoembryonic antigen(CEA)and carbohydrate antigen 125(CA125)in both groups decreased,with more reduction detected in the observation group(P<0.05).Compare with the control group,the recurrence rates at 6 and 12 months in the observation group were lower,and the survival rates were higher,even though the difference between the two groups was not significant(P>0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusions:Xihuang pill combined with neoadjuvant chemotherapy can improve the prognosis of patients with advanced cervical cancer,improve the curative effect,regulate cellular immune function and reduce adverse reactions.